{"id":365822,"date":"2026-01-08T08:29:40","date_gmt":"2026-01-08T07:29:40","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=365822"},"modified":"2026-01-08T08:29:40","modified_gmt":"2026-01-08T07:29:40","slug":"ceska-republika-vedci-pozorovali-jak-bakterie-rodu-bordetella-napadaji-bunky-hostitele","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=365822","title":{"rendered":"\u010cESK\u00c1 REPUBLIKA: V\u011bdci pozorovali, jak bakterie rodu Bordetella napadaj\u00ed bu\u0148ky hostitele"},"content":{"rendered":"
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Ilustra\u010dn\u00ed foto: pixabay<\/figcaption><\/figure>\n

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Bakterie rodu Bordetella, p\u016fvodci \u010dern\u00e9ho ka\u0161le a dal\u0161\u00edch respira\u010dn\u00edch onemocn\u011bn\u00ed savc\u016f, m\u011bn\u00ed tvar sv\u00e9ho infek\u010dn\u00edho apar\u00e1tu b\u011bhem napaden\u00ed hostitelsk\u00fdch bun\u011bk. T\u00fdm v\u011bdc\u016f z Mikrobiologick\u00e9ho \u00fastavu Akademie v\u011bd \u010cesk\u00e9 republiky (MB\u00da AV \u010cR) odhalil, jak to d\u011blaj\u00ed. Sledovali protein Bsp22, kter\u00fd tvo\u0159\u00ed jehle podobn\u00fd v\u00fdb\u011b\u017eek na povrchu bakterie, a zjistili, \u017ee se tento \u00fatvar dok\u00e1\u017ee pru\u017en\u011b p\u0159izp\u016fsobovat podm\u00ednk\u00e1m prost\u0159ed\u00ed. Objev p\u0159in\u00e1\u0161\u00ed nov\u00e9 poznatky o mechanismech infekce a m\u016f\u017ee pomoci p\u0159i v\u00fdvoji \u00fa\u010dinn\u011bj\u0161\u00edch strategi\u00ed prevence a l\u00e9\u010dby onemocn\u011bn\u00ed.<\/h6>\n

\"\"Bakterie rodu Bordetella vyu\u017e\u00edvaj\u00ed nanostruktury podobn\u00e9 injek\u010dn\u00ed st\u0159\u00edka\u010dce, je\u017e jim umo\u017e\u0148uj\u00ed vst\u0159\u00edknout do hostitelsk\u00e9 bu\u0148ky r\u016fzn\u00e9 proteiny, kter\u00e9 podporuj\u00ed rozvoj onemocn\u011bn\u00ed a manipuluj\u00ed sign\u00e1ln\u00edmi drahami \u010di obranou hostitele ve sv\u016fj prosp\u011bch. Tyto nanostruktury obsahuj\u00ed protein Bsp22, jen\u017e tvo\u0159\u00ed unik\u00e1tn\u00ed vl\u00e1knit\u00fd \u00fatvar na jejich konci. V\u00fdzkumn\u00fd t\u00fdm se zam\u011b\u0159il na pochopen\u00ed mechanism\u016f dynamick\u00e9 regulace vl\u00e1ken Bsp22. Pr\u00e1v\u011b tento ozna\u010den\u00fd protein jim umo\u017enil sledovat zm\u011bny v d\u00e9lce a mno\u017estv\u00ed vl\u00e1ken pomoc\u00ed vysoce rozli\u0161uj\u00edc\u00ed mikroskopie a zjistit, jak se bakterie dok\u00e1\u017eou p\u0159izp\u016fsobovat r\u016fzn\u00fdm prost\u0159ed\u00edm. Porozum\u011bn\u00ed t\u011bmto mechanism\u016fm m\u016f\u017ee v\u00e9st k v\u00fdvoji nov\u00fdch strategi\u00ed pro prevenci a l\u00e9\u010dbu onemocn\u011bn\u00ed, kter\u00e9 tyto bakterie zp\u016fsobuj\u00ed.<\/p>\n

\u201eV\u00fdzvou bylo um\u00edstit tuto zna\u010dku tak, aby nebyla ovlivn\u011bna funk\u010dnost \u201abakteri\u00e1ln\u00ed jehly\u00b4, do n\u00ed\u017e se protein Bsp22 skl\u00e1d\u00e1,\u201c<\/em> up\u0159es\u0148uje Ivana Malcov\u00e1 z MB\u00da AV \u010cR a dod\u00e1v\u00e1: \u201eD\u00edky tomu jsme mohli sledovat, jak bakterie upravuj\u00ed d\u00e9lku vl\u00e1kna jehly b\u011bhem napaden\u00ed hostitele.\u201c<\/em><\/p>\n

V\u011bdci odhalili, \u017ee protein Bsp22 se skl\u00e1d\u00e1 do ohebn\u00fdch vl\u00e1ken, kter\u00e1 vyr\u016fstaj\u00ed z povrchu bakterie a mohou dosahovat d\u00e9lky a\u017e n\u011bkolika mikrometr\u016f. Prok\u00e1zali, \u017ee nov\u00e9 podjednotky Bsp22 se p\u0159id\u00e1vaj\u00ed na jejich konce, \u010d\u00edm\u017e se vl\u00e1kna neust\u00e1le prodlu\u017euj\u00ed.<\/p>\n

\u201eZjistili jsme, \u017ee b\u011bhem infekce hostitelsk\u00fdch bun\u011bk jsou vl\u00e1kna Bsp22 krat\u0161\u00ed a m\u00e9n\u011b po\u010detn\u00e1 ne\u017e p\u0159i kultivaci v \u017eivn\u00e9m m\u00e9diu,\u201c<\/em> vysv\u011btluje Jana Kamanov\u00e1, vedouc\u00ed Laborato\u0159e bun\u011b\u010dn\u00e9 biologie infekc\u00ed v MB\u00da AV \u010cR, a dod\u00e1v\u00e1: \u201eZkr\u00e1cen\u00e1 vl\u00e1kna z\u016fst\u00e1vaj\u00ed p\u0159esto funk\u010dn\u00ed a schopn\u00e1 doru\u010dovat proteiny do napaden\u00fdch bun\u011bk.\u201c<\/em> Studie tak p\u0159in\u00e1\u0161\u00ed d\u016fle\u017eit\u00e9 poznatky o tom, jak se bakterie rodu Bordetella dok\u00e1\u017eou p\u0159izp\u016fsobovat r\u016fzn\u00fdm podm\u00ednk\u00e1m prost\u0159ed\u00ed. Nov\u00e9 poznatky publikoval presti\u017en\u00ed \u010dasopis mBio<\/strong><\/a>.<\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

  Bakterie <\/p>\n","protected":false},"author":2,"featured_media":365823,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[128,174],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2026\/01\/08\/bakterie.webp","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/365822"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=365822"}],"version-history":[{"count":1,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/365822\/revisions"}],"predecessor-version":[{"id":365824,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/365822\/revisions\/365824"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/365823"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=365822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=365822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=365822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}