{"id":363230,"date":"2025-12-02T11:08:04","date_gmt":"2025-12-02T10:08:04","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=363230"},"modified":"2025-12-02T11:08:04","modified_gmt":"2025-12-02T10:08:04","slug":"aktuality-matka-predava-rytmicke-metabolicke-signaly-mozku-plodu-drive-nez-se-rozbehnou-jeho-vlastni-hodiny","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=363230","title":{"rendered":"AKTUALITY: Matka p\u0159ed\u00e1v\u00e1 rytmick\u00e9 metabolick\u00e9 sign\u00e1ly mozku plodu d\u0159\u00edve, ne\u017e se rozb\u011bhnou jeho vlastn\u00ed hodiny"},"content":{"rendered":"

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Matka komunikuje s mozkem vyv\u00edjej\u00edc\u00edho se plodu pomoc\u00ed rytmick\u00fdch metabolick\u00fdch sign\u00e1l\u016f je\u0161t\u011b p\u0159ed t\u00edm, ne\u017e se u n\u011bj pln\u011b vyvinou jeho vlastn\u00ed biologick\u00e9 hodiny, zjistil t\u00fdm Aleny Sumov\u00e9 z Fyziologick\u00e9ho \u00fastavu AV \u010cR. Nov\u00e1 studie publikovan\u00e1 v presti\u017en\u00edm \u010dasopise PLOS Biology p\u0159in\u00e1\u0161\u00ed pr\u016flomov\u00e9 poznatky o v\u00fdvoji cirkadi\u00e1nn\u00edch rytm\u016f u savc\u016f a odhaluje d\u0159\u00edve nezn\u00e1m\u00e9 metabolick\u00e9 sign\u00e1ly, kter\u00e9 matka p\u0159ed\u00e1v\u00e1 plodu prost\u0159ednictv\u00edm v\u00fd\u017eivy.<\/h6>\n

V\u00fdzkumn\u00fd t\u00fdm analyzoval v\u00fdvoj molekul\u00e1rn\u00edch cirkadi\u00e1nn\u00edch hodin u potkan\u016f od prenat\u00e1ln\u00edho obdob\u00ed a\u017e po dosp\u011blost.<\/p>\n

\u201eNa\u0161e v\u00fdsledky ukazuj\u00ed, \u017ee ji\u017e p\u0159ed t\u00edm, ne\u017e se u plodu spust\u00ed vlastn\u00ed cirkadi\u00e1nn\u00ed hodiny, jsou v jeho mozku p\u0159\u00edtomny rytmick\u00e9 metabolick\u00e9 sign\u00e1ly poch\u00e1zej\u00edc\u00ed z mate\u0159sk\u00e9 stravy,”<\/em> vysv\u011btluje hlavn\u00ed autorka studie Alena Sumov\u00e1, vedouc\u00ed Odd\u011blen\u00ed biologick\u00fdch rytm\u016f ve Fyziologick\u00e9m \u00fastavu AV \u010cR (FG\u00da AV \u010cR). \u201eIdentifikovali jsme rytmy v hladin\u00e1ch esenci\u00e1ln\u00edch aminokyselin, karnitin\u016f a nukleosid\u016f v mozku plodu, kter\u00e9 miz\u00ed po narozen\u00ed a znovu se objevuj\u00ed a\u017e po odstaven\u00ed ml\u00e1\u010fat.”<\/em><\/p>\n

Studie prok\u00e1zala, \u017ee cirkadi\u00e1nn\u00ed hodiny se u potkan\u00edch plod\u016f rozv\u00edjej\u00ed postupn\u011b. V 19. dni embryon\u00e1ln\u00edho v\u00fdvoje, tedy 2 a\u017e 3 dny p\u0159ed narozen\u00edm, je\u0161t\u011b nejsou pln\u011b funk\u010dn\u00ed. P\u0159esto metabolismus v jejich mozku vykazuje 24hodinov\u00e9 rytmy \u2013 co\u017e nazna\u010duje, \u017ee tyto rytmy jsou \u0159\u00edzeny sign\u00e1ly z mate\u0159sk\u00e9ho organismu, nikoli vlastn\u00edmi hodinami plodu.<\/p>\n

Aplikace COMA: Interaktivn\u00ed atlas cirkadi\u00e1nn\u00ed metabolomiky Velk\u00fdm p\u0159\u00ednosem projektu bylo vyu\u017eit\u00ed voln\u011b dostupn\u00e9 nov\u00e9 webov\u00e9 aplikace COMA (Circadian Ontogenetic Metabolomics Atlas), kter\u00e1 vznikla v roce 2025 ve Fyziologick\u00e9m \u00fastavu AV \u010cR s podporou N\u00e1rodn\u00edho institutu CarDia. Jedn\u00e1 se o interaktivn\u00ed otev\u0159enou datab\u00e1zi, kter\u00e1 detailn\u011b mapuje cirkadi\u00e1nn\u00ed (denn\u00ed) metabolick\u00e9 rytmy v \u0161estn\u00e1cti anatomick\u00fdch struktur\u00e1ch potkana v r\u016fzn\u00fdch v\u00fdvojov\u00fdch f\u00e1z\u00edch. COMA obsahuje kompletn\u00ed dataset metabolomick\u00fdch a lipidomick\u00fdch profil\u016f z r\u016fzn\u00fdch tk\u00e1n\u00ed v pr\u016fb\u011bhu v\u00fdvoje, kter\u00fd je ur\u010den pro \u0161irokou v\u011bdeckou komunitu.<\/p>\n

\u201eCOMA p\u0159edstavuje unik\u00e1tn\u00ed v\u00fdzkumn\u00fd n\u00e1stroj, kter\u00fd umo\u017e\u0148uje v\u011bdc\u016fm z cel\u00e9ho sv\u011bta proch\u00e1zet na\u0161imi daty, generovat vlastn\u00ed grafy a objevovat nov\u00e9 souvislosti mezi cirkadi\u00e1nn\u00edmi rytmy a metabolismem,”<\/em> dod\u00e1v\u00e1 spoluautor studie Tom\u00e1\u0161 \u010cajka z FG\u00da AV \u010cR, kter\u00fd spolu s Alenou Sumovou stoj\u00ed za jej\u00edm vznikem. Aplikace je v\u00fdsledkem dlouhodob\u00e9 snahy o otev\u0159enou v\u011bdu a zaji\u0161\u0165uje, \u017ee data budou slou\u017eit dal\u0161\u00edm badatel\u016fm v oblasti chronobiologie a metabolomiky.<\/p>\n

Vliv denn\u00edho rytmu matky na zdrav\u00ed d\u00edt\u011bte<\/h6>\n

V\u00fdzkum finan\u010dn\u011b podpo\u0159ily Grantov\u00e1 agentura \u010cesk\u00e9 republiky a N\u00e1rodn\u00ed \u00fastav prov\u00fdzkum metabolick\u00fdch a kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed (CarDia) v r\u00e1mci programu EXCELES financovan\u00e9ho Evropskou uni\u00ed prost\u0159ednictv\u00edm iniciativy Next Generation EU.<\/p>\n

\u201eProgram EXCELES n\u00e1m umo\u017enil vyu\u017e\u00edt nejmodern\u011bj\u0161\u00ed metabolomickou infrastrukturu a propojit v\u00fdzkum z\u00e1kladn\u00edch mechanism\u016f biologick\u00fdch hodin s aplikovan\u00fdm v\u00fdzkumem metabolick\u00fdch onemocn\u011bn\u00ed,”<\/em> dod\u00e1v\u00e1 Martin Sl\u00e1dek z FG\u00da, prvn\u00ed autor studie. \u201ePropojen\u00ed cirkadi\u00e1nn\u00edch rytm\u016f s metabolismem m\u00e1 z\u00e1sadn\u00ed v\u00fdznam pro pochopen\u00ed vzniku civiliza\u010dn\u00edch chorob v\u010detn\u011b obezity, diabetu nebo kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed.”<\/em><\/p>\n

V\u00fdsledky studie maj\u00ed dalekos\u00e1hl\u00e9 d\u016fsledky pro perinat\u00e1ln\u00ed medic\u00ednu. Naru\u0161en\u00ed mate\u0159sk\u00fdch cirkadi\u00e1nn\u00edch rytm\u016f \u2013 nap\u0159\u00edklad v d\u016fsledku pr\u00e1ce na sm\u011bny nebo nezdrav\u00e9ho \u017eivotn\u00edho stylu b\u011bhem t\u011bhotenstv\u00ed \u2013 by mohlo ovlivnit nastaven\u00ed biologick\u00fdch hodin u potomka a zv\u00fd\u0161it riziko metabolick\u00fdch poruch v pozd\u011bj\u0161\u00edm \u017eivot\u011b.<\/p>\n

\u201eNa\u0161e zji\u0161t\u011bn\u00ed otev\u00edraj\u00ed nov\u00e9 mo\u017enosti pro prevenci metabolick\u00fdch a kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed ji\u017e v prenat\u00e1ln\u00edm obdob\u00ed,”<\/em> uzav\u00edr\u00e1 Alena Sumov\u00e1. \u201ePochopen\u00ed toho, jak matka synchronizuje biologick\u00e9 hodiny plodu, m\u016f\u017ee v\u00e9st k doporu\u010den\u00edm pro t\u011bhotn\u00e9 \u017eeny ohledn\u011b pravidelnosti j\u00eddla a denn\u00edho re\u017eimu.”<\/em><\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

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