{"id":360938,"date":"2025-11-13T14:01:13","date_gmt":"2025-11-13T13:01:13","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=360938"},"modified":"2025-11-13T14:01:13","modified_gmt":"2025-11-13T13:01:13","slug":"ceska-republika-houby-si-pri-sireni-kozni-infekce-z-morcat-na-cloveka-mohou-pomahat-toxickymi-latkami","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=360938","title":{"rendered":"\u010cESK\u00c1 REPUBLIKA: Houby si p\u0159i \u0161\u00ed\u0159en\u00ed ko\u017en\u00ed infekce z mor\u010dat na \u010dlov\u011bka mohou pom\u00e1hat toxick\u00fdmi l\u00e1tkami"},"content":{"rendered":"
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Ilustra\u010dn\u00ed foto: pixabay<\/figcaption><\/figure>\n

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Ko\u017en\u00ed infekce, kter\u00e9 se \u0161\u00ed\u0159\u00ed od dom\u00e1c\u00edch mor\u010dat na lidi, zp\u016fsobuje houba Trichophyton benhamiae var. luteum. Nov\u00e1 studie t\u00fdmu z Mikrobiologick\u00e9ho \u00fastavu Akademie v\u011bd \u010cR nyn\u00ed odhaluje, pro\u010d je tak \u00fasp\u011b\u0161n\u00e1 \u2013 z\u0159ejm\u011b si pom\u00e1h\u00e1 tvorbou l\u00e1tek podobn\u00fdch toxin\u016fm.<\/h6>\n

\"\"Houbu Trichophyton benhamiae var. luteum popsali \u010de\u0161t\u00ed v\u011bdci p\u0159ed n\u011bkolika lety jako p\u016fvodce epidemie, kter\u00e1 zas\u00e1hla mnoho d\u011bt\u00ed nap\u0159\u00ed\u010d Evropou. Onemocn\u011bn\u00ed, kter\u00e9 p\u0159en\u00e1\u0161ej\u00ed mor\u010data na lidi, zejm\u00e9na na d\u011bti, se projevuje v\u00fdraznou vyr\u00e1\u017ekou a z\u00e1n\u011btem k\u016f\u017ee, nej\u010dast\u011bji na obli\u010deji nebo ruk\u00e1ch.<\/p>\n

V nov\u00e9 studii se t\u00fdm z Mikrobiologick\u00e9ho \u00fastavu AV \u010cR zam\u011b\u0159il na d\u016fvod snadn\u00e9ho \u0161\u00ed\u0159en\u00ed t\u00e9to infekce. Prok\u00e1zal, \u017ee houba z\u0159ejm\u011b vyu\u017e\u00edv\u00e1 toxick\u00e9 l\u00e1tky, kter\u00e9 mohou oslabovat imunitn\u00ed reakci hostitele, a t\u00edm usnadnit houb\u011b p\u0159enos mezi mor\u010daty, z mor\u010dete na \u010dlov\u011bka i mezi lidmi navz\u00e1jem.<\/p>\n

Trichophyton benhamiae var. luteum m\u00e1 sice bl\u00edzk\u00e9 p\u0159\u00edbuzn\u00e9 v Evrop\u011b i v Americe, ti se v\u0161ak \u0161\u00ed\u0159\u00ed mnohem pomaleji a jen v\u00fdjime\u010dn\u011b zp\u016fsobuj\u00ed infekce. \u201eLuteum\u201c varianta se tedy zd\u00e1 evolu\u010dn\u011b v\u00fdjime\u010dn\u011b p\u0159izp\u016fsoben\u00e1 k p\u0159enosu mezi mor\u010detem a \u010dlov\u011bkem.<\/p>\n

\u201eZjistili jsme, \u017ee pr\u00e1v\u011b geny spojen\u00e9 se sekund\u00e1rn\u00edmi metabolity \u2013 tedy l\u00e1tkami, kter\u00e9 houba vytv\u00e1\u0159\u00ed mimo svou b\u011b\u017enou l\u00e1tkovou v\u00fdm\u011bnu \u2013 jsou u tohoto ko\u017en\u00edho patogenu v\u00fdrazn\u011b aktivn\u011bj\u0161\u00ed,\u201c<\/em> vysv\u011btluje prvn\u00ed autorka studie Lenka Machov\u00e1 z Mikrobiologick\u00e9ho \u00fastavu AV \u010cR (MB\u00da AV \u010cR).<\/p>\n

Krom\u011b laboratorn\u00edch experiment\u016f t\u00fdm vyu\u017eil i model ko\u017en\u00ed infekce na tk\u00e1n\u00edch, kter\u00fd napodobuje re\u00e1ln\u00e9 podm\u00ednky v my\u0161\u00ed k\u016f\u017ei. \u201eTo n\u00e1m umo\u017enilo zjistit, jak houba reaguje ve sv\u00e9m p\u0159irozen\u00e9m prost\u0159ed\u00ed,\u201c<\/em> dopl\u0148uje vedouc\u00ed v\u00fdzkumn\u00e9ho t\u00fdmu Ad\u00e9la Wennrich z MB\u00da AV \u010cR.<\/p>\n

Podle vedouc\u00edho Laborato\u0159e genetiky a metabolismu hub v MB\u00da AV \u010cR Miroslava Kola\u0159\u00edka jde o d\u016fle\u017eit\u00fd p\u0159\u00edsp\u011bvek k pochopen\u00ed mechanism\u016f, kter\u00e9 umo\u017e\u0148uj\u00ed n\u011bkter\u00fdm druh\u016fm dermatofyt rychle se \u0161\u00ed\u0159it a infikovat nov\u00e9 hostitele.<\/p>\n

\u201eTakov\u00e1 znalost je kl\u00ed\u010dov\u00e1 pro v\u00fdvoj nov\u00fdch diagnostick\u00fdch n\u00e1stroj\u016f a l\u00e9\u010debn\u00fdch strategi\u00ed \u2013 a tak\u00e9 pro ochranu ve\u0159ejn\u00e9ho zdrav\u00ed,\u201c<\/em> \u0159\u00edk\u00e1 v\u011bdec.<\/p>\n

Dal\u0161\u00ed v\u00fdzkum se nyn\u00ed zam\u011b\u0159\u00ed na to, jak\u00e1 je povaha n\u011bkter\u00fdch z t\u011bchto toxick\u00fdch l\u00e1tek a jak p\u0159esn\u011b p\u016fsob\u00ed na lidsk\u00e9 bu\u0148ky. Lep\u0161\u00ed pochopen\u00ed jejich mechanismu by v budoucnu mohlo umo\u017enit c\u00edlen\u011b zasahovat tento faktor virulence, tj. schopnost vyvolat nemoc, nap\u0159\u00edklad p\u0159i v\u00fdvoji nov\u00fdch l\u00e9\u010debn\u00fdch p\u0159\u00edstup\u016f.<\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

\n

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