{"id":357485,"date":"2025-09-25T09:15:48","date_gmt":"2025-09-25T08:15:48","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=357485"},"modified":"2025-09-25T09:15:48","modified_gmt":"2025-09-25T08:15:48","slug":"aktuality-paracetamol-zustava-vhodnou-lecbou-zavaznych-bolesti-a-horecky-behem-tehotenstvi","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=357485","title":{"rendered":"AKTUALITY: Paracetamol z\u016fst\u00e1v\u00e1 vhodnou l\u00e9\u010dbou z\u00e1va\u017en\u00fdch bolest\u00ed a hore\u010dky b\u011bhem t\u011bhotenstv\u00ed"},"content":{"rendered":"

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St\u00e1tn\u00ed \u00fastav pro kontrolu l\u00e9\u010div se p\u0159ipojuje k aktu\u00e1ln\u00edmu\u00a0stanovisku Evropsk\u00e9 agentury pro l\u00e9\u010div\u00e9 p\u0159\u00edpravky (EMA)<\/a>, kter\u00e9 potvrzuje, \u017ee l\u00e9\u010div\u00e1 l\u00e1tka paracetamol z\u016fst\u00e1v\u00e1 d\u016fle\u017eitou mo\u017enost\u00ed l\u00e9\u010dby bolesti nebo hore\u010dky u t\u011bhotn\u00fdch \u017een.<\/h6>\n
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V EU i\u00a0nad\u00e1le plat\u00ed doporu\u010den\u00ed pro u\u017e\u00edv\u00e1n\u00ed paracetamolu v\u00a0t\u011bhotenstv\u00ed tak, jak je uvedeno ve schv\u00e1len\u00e9m textu souhrnu informac\u00ed o\u00a0p\u0159\u00edpravku (SmPC) pro l\u00e9\u010div\u00e9 p\u0159\u00edpravky s\u00a0obsahem paracetamolu:<\/p>\n

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T\u011bhotenstv\u00ed<\/h6>\n

Paracetamol proch\u00e1z\u00ed placent\u00e1rn\u00ed bari\u00e9rou. Velk\u00e9 mno\u017estv\u00ed dat u t\u011bhotn\u00fdch \u017een neukazuje na malforma\u010dn\u00ed toxicitu ani na toxick\u00fd vliv na plod\/novorozence. V\u00fdsledky epidemiologick\u00fdch studi\u00ed neurologick\u00e9ho v\u00fdvoje u d\u011bt\u00ed, kter\u00e9 byly v d\u011bloze b\u011bhem t\u011bhotenstv\u00ed vystaveny paracetamolu, nejsou pr\u016fkazn\u00e9. Pokud je to z klinick\u00e9ho hlediska zapot\u0159eb\u00ed, m\u016f\u017ee b\u00fdt paracetamol pod\u00e1v\u00e1n b\u011bhem t\u011bhotenstv\u00ed, nicm\u00e9n\u011b by m\u011bla b\u00fdt pou\u017eita nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e1 d\u00e1vka po co nejkrat\u0161\u00ed mo\u017enou dobu a s nejni\u017e\u0161\u00ed mo\u017enou frekvenc\u00ed.<\/p>\n<\/div>\n<\/div>\n

V roce 2019 EMA posoudila dostupn\u00e9 studie, kter\u00e9 zkoumaly souvislost mezi u\u017e\u00edv\u00e1n\u00edm paracetamolu v\u00a0t\u011bhotenstv\u00ed a\u00a0neurologick\u00fdm v\u00fdvojem d\u011bt\u00ed. Agentura dosp\u011bla k\u00a0z\u00e1v\u011bru, \u017ee v\u00fdsledky studi\u00ed jsou nepr\u016fkazn\u00e9, tedy \u017ee nelze prok\u00e1zat \u017e\u00e1dnou souvislost s\u00a0neurov\u00fdvojov\u00fdmi poruchami u\u00a0d\u011bt\u00ed.<\/p>\n

Ned\u00e1vn\u00e1 rozs\u00e1hl\u00e1 \u0161v\u00e9dsk\u00e1 studie publikovan\u00e1 v\u00a0\u010dasopise JAMA v\u00a0dubnu 2024, kter\u00e1 zahrnovala v\u00edce ne\u017e 2,4 milionu d\u011bt\u00ed, rovn\u011b\u017e nena\u0161la \u017e\u00e1dnou souvislost mezi u\u017e\u00edv\u00e1n\u00edm paracetamolu b\u011bhem t\u011bhotenstv\u00ed a\u00a0zv\u00fd\u0161en\u00fdm rizikem autismu, ADHD nebo ment\u00e1ln\u00edho posti\u017een\u00ed.<\/p>\n

Ostatn\u011b i\u00a0\u00da\u0159ad pro kontrolu potravin a\u00a0l\u00e9\u010div (USA) ve sv\u00e9m\u00a0sd\u011blen\u00ed ze dne 22.\u00a09.\u00a02025<\/a><\/strong>\u00a0uv\u00e1d\u00ed, \u017ee p\u0159\u00ed\u010dinn\u00e1 souvislost mezi u\u017e\u00edv\u00e1n\u00edm paracetamolu v\u00a0t\u011bhotenstv\u00ed a\u00a0v\u00fdskytem autismu u\u00a0d\u011bt\u00ed nebyla prok\u00e1z\u00e1na. Rovn\u011b\u017e poukazuje na to, \u017ee hore\u010dka b\u011bhem t\u011bhotenstv\u00ed m\u016f\u017ee b\u00fdt rizikem pro plod, proto paracetamol v\u00a0opodstatn\u011bn\u00fdch situac\u00edch z\u016fst\u00e1v\u00e1 vhodn\u00fdm l\u00e9kem pro t\u011bhotnou \u017eenu.<\/p>\n

V sou\u010dasn\u00e9 dob\u011b nejsou dostupn\u00e9 \u017e\u00e1dn\u00e9 nov\u00e9 \u00fadaje, kter\u00e9 by vy\u017eadovaly zm\u011bnu uveden\u00fdch doporu\u010den\u00ed. Bezpe\u010dnost paracetamolu (stejn\u011b jako v\u0161ech ostatn\u00edch l\u00e9\u010div\u00fdch p\u0159\u00edpravk\u016f registrovan\u00fdch v\u00a0EU) je trvale pr\u016fb\u011b\u017en\u011b sledov\u00e1na a\u00a0p\u0159i\u00a0objeven\u00ed se nov\u00fdch \u00fadaj\u016f je v\u017edy nov\u011b p\u0159ehodnocov\u00e1n pom\u011br p\u0159\u00ednos\u016f a\u00a0rizik, v\u00a0p\u0159\u00edpad\u011b pot\u0159eby jsou zav\u00e1d\u011bna nov\u00e1 opat\u0159en\u00ed.<\/p>\n

V t\u011bhotenstv\u00ed plat\u00ed obecn\u00e9 pravidlo, \u017ee se nem\u00e1 u\u017e\u00edvat \u017e\u00e1dn\u00fd l\u00e9k, pokud nen\u00ed zcela nezbytn\u00fd. Na druh\u00e9 stran\u011b v\u0161ak z\u00e1va\u017en\u00fd nel\u00e9\u010den\u00fd stav m\u016f\u017ee po\u0161kodit jak t\u011bhotnou \u017eenu, tak i jej\u00ed plod mnohem v\u00edce, ne\u017e vlastn\u00ed l\u00e9\u010dba. Pokud m\u00e1 t\u011bhotn\u00e1 \u017eena hore\u010dku, je paracetamol i p\u0159i mal\u00e9 m\u00ed\u0159e nejasnost\u00ed nejbezpe\u010dn\u011bj\u0161\u00ed l\u00e9\u010dbou. Upozor\u0148ujeme, \u017ee ibuprofen ani jin\u00e1 nesteroidn\u00ed antirevmatika (v\u010detn\u011b acetylsalicylov\u00e9 kyseliny) nejsou vhodnou alternativou pro t\u011bhotnou \u017eenu \u2013 v 1. a 2. trimestru t\u011bhotenstv\u00ed se nemaj\u00ed u\u017e\u00edvat, pokud to nen\u00ed absolutn\u011b nutn\u00e9, proto\u017ee mohou zp\u016fsobit zv\u00fd\u0161en\u00e9 riziko potrat\u016f, malformac\u00ed srdce a \u017ealudku; ve 3. trimestru jsou pro nep\u0159\u00edzniv\u00fd vliv na t\u011bhotnou \u017eenu, plod i pr\u016fb\u011bh porodu kontraindikov\u00e1ny.<\/p>\n

(tz-sz\u00fa)\u00a0<\/strong><\/p>\n<\/div>\n

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