{"id":354863,"date":"2025-08-26T07:28:58","date_gmt":"2025-08-26T06:28:58","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=354863"},"modified":"2025-08-26T07:28:58","modified_gmt":"2025-08-26T06:28:58","slug":"aktuality-nova-ceska-studie-prinasi-zasadni-poznatky-o-vyvoji-krvetvorby-u-novorozenych-deti","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=354863","title":{"rendered":"AKTUALITY: Nov\u00e1 \u010desk\u00e1 studie p\u0159in\u00e1\u0161\u00ed z\u00e1sadn\u00ed poznatky o v\u00fdvoji krvetvorby u novorozen\u00fdch d\u011bt\u00ed"},"content":{"rendered":"

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B\u011bhem nitrod\u011blo\u017en\u00edho v\u00fdvoje jsou j\u00e1tra hlavn\u00edm m\u00edstem tvorby krevn\u00edch bun\u011bk. Kr\u00e1tce po narozen\u00ed v\u0161ak tato aktivita prudce kles\u00e1 a krvetvorba se p\u0159esouv\u00e1 do kostn\u00ed d\u0159en\u011b. Tento proces nebyl dosud u lidsk\u00fdch novorozenc\u016f dostate\u010dn\u011b prozkoum\u00e1n, zejm\u00e9na kv\u016fli nedostatku vhodn\u00fdch vzork\u016f. V\u011bdci z Fyziologick\u00e9ho \u00fastavu AV \u010cR a 1. l\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy v Praze nyn\u00ed publikovali studii, kter\u00e1 p\u0159in\u00e1\u0161\u00ed nov\u00e9 poznatky o rozd\u00edln\u00e9m \u00fatlumu tvorby jednotliv\u00fdch lini\u00ed krevn\u00edch bun\u011bk po narozen\u00ed.<\/h6>\n

T\u00fdm veden\u00fd Janem Kopeck\u00fdm z Odd\u011blen\u00ed biologie tukov\u00e9 tk\u00e1n\u011b Fyziologick\u00e9ho \u00fastavu AV \u010cR popsal, jak se po porodu krvetvorba (hematopo\u00e9za) v j\u00e1trech novorozenc\u016f m\u011bn\u00ed. V\u011bdci analyzovali vz\u00e1cn\u00e9 vzorky jater odebran\u00fdch z 25 p\u0159ev\u00e1\u017en\u011b p\u0159ed\u010dasn\u011b narozen\u00fdch d\u011bt\u00ed, kter\u00e9 zem\u0159ely v prvn\u00edch hodin\u00e1ch \u010di dnech po porodu. Pomoc\u00ed kombinace klasick\u00e9ho imunohistologick\u00e9ho p\u0159\u00edstupu a pokro\u010dil\u00fdch metod molekul\u00e1rn\u00ed biologie poskytuj\u00edc\u00edch informace o zapnut\u00ed jednotliv\u00fdch gen\u016f detailn\u011b popsali pr\u016fb\u011bh \u00fatlumu r\u016fzn\u00fdch v\u011btv\u00ed krvetvorby.<\/p>\n

V\u011bdci odhalili, \u017ee tvorba \u010derven\u00fdch krvinek (erytrocyt\u016f) v j\u00e1trech novorozenc\u016f po narozen\u00ed kles\u00e1 velmi rychle \u2013 ji\u017e b\u011bhem t\u0159\u00ed dn\u016f od porodu. Proti tomu se tvorba b\u00edl\u00fdch krvinek (granulopo\u00e9za) v j\u00e1trech utlumuje pomaleji, co\u017e p\u0159echodn\u011b vede k vy\u0161\u0161\u00edmu pod\u00edlu t\u011bchto bun\u011bk v tk\u00e1ni v porovn\u00e1n\u00ed s erytrocyty.<\/p>\n

\u201eCelkov\u00fd pokles krvetvorn\u00e9 aktivity v j\u00e1trech z\u00e1vis\u00ed jak na d\u00e9lce t\u011bhotenstv\u00ed (gesta\u010dn\u00edm st\u00e1\u0159\u00ed) d\u00edt\u011bte, tak na dob\u011b, kter\u00e1 uplynula od porodu, nicm\u00e9n\u011b nejv\u011bt\u0161\u00ed vliv m\u00e1 samotn\u00fd moment narozen\u00ed,\u201c<\/em> \u0159\u00edk\u00e1 vedouc\u00ed v\u00fdzkumu Jan Kopeck\u00fd.<\/p>\n

Lep\u0161\u00ed pochopen\u00ed probl\u00e9m\u016f u p\u0159ed\u010dasn\u011b narozen\u00fdch d\u011bt\u00ed<\/h6>\n

V\u00fdzkum z\u00e1rove\u0148 identifikoval konkr\u00e9tn\u00ed geny a transkrip\u010dn\u00ed faktory, kter\u00e9 jednotliv\u00e9 v\u011btve krvetvorby v j\u00e1trech novorozenc\u016f po porodu specificky ovliv\u0148uj\u00ed.<\/p>\n

\u201eNov\u00e9 v\u00fdsledky ukazuj\u00ed, jak rychle a rozd\u00edln\u011b se po porodu vyv\u00edjej\u00ed jednotliv\u00e9 linie krevn\u00edch bun\u011bk v j\u00e1trech. Pom\u00e1haj\u00ed l\u00e9pe pochopit probl\u00e9my p\u0159ed\u010dasn\u011b narozen\u00fdch d\u011bt\u00ed s krvetvorbou a po\u010dtem krvinek a mohou p\u0159isp\u011bt i k v\u00fdvoji nov\u00fdch terapeutick\u00fdch postup\u016f,\u201c<\/em> dopl\u0148uje dal\u0161\u00ed z autor\u016f studie Petr Zouhar z Fyziologick\u00e9ho \u00fastavu AV \u010cR.<\/p>\n

Studie publikovan\u00e1 v \u010dasopise Frontiers in Pediatrics byla umo\u017en\u011bna d\u00edky unik\u00e1tn\u00ed biobance vzork\u016f dlouhodob\u011b budovan\u00e9 se souhlasem rodi\u010d\u016f. V\u00fdzkum podpo\u0159ilo Ministerstvo zdravotnictv\u00ed \u010cR (grant NU20-07-00026).<\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

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  B\u011bhem <\/p>\n","protected":false},"author":2,"featured_media":354864,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[179,174],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2025\/08\/26\/nove-krvetvorba.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/354863"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=354863"}],"version-history":[{"count":1,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/354863\/revisions"}],"predecessor-version":[{"id":354865,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/354863\/revisions\/354865"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/354864"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=354863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=354863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=354863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}