{"id":352852,"date":"2025-08-02T19:11:53","date_gmt":"2025-08-02T18:11:53","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=352852"},"modified":"2025-08-02T19:42:52","modified_gmt":"2025-08-02T18:42:52","slug":"aktuality-hodiny-v-mozku-slouzi-jako-senzor-denniho-rezimu","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=352852","title":{"rendered":"AKTUALITY: Hodiny v mozku slou\u017e\u00ed jako senzor denn\u00edho re\u017eimu"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-243085 size-large\" src=\"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1024x275.png\" alt=\"\" width=\"700\" height=\"188\" srcset=\"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1024x275.png 1024w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-300x80.png 300w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-768x206.png 768w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1331x357.png 1331w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1801x483.png 1801w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h6>Nov\u00fd v\u00fdzkum t\u00fdmu z Fyziologick\u00e9ho \u00fastavu AV \u010cR ukazuje, \u017ee biologick\u00e9 hodiny v choroidn\u00edm plexu \u2013 tk\u00e1ni v mozkov\u00fdch komor\u00e1ch, kter\u00e1 se pod\u00edl\u00ed na tvorb\u011b mozkom\u00ed\u0161n\u00edho moku \u2013 jsou \u0159\u00edzeny nejen sv\u011btlem, ale i na\u010dasov\u00e1n\u00edm p\u0159\u00edjmu potravy. V\u00fdsledky studie publikovan\u00e9 v \u010dasopise <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-05798-3\" target=\"_blank\" rel=\"noopener\">Cellular and Molecular Life Sciences<\/a> odhaluj\u00ed, \u017ee tyto hodiny mohou b\u00fdt rychle p\u0159eprogramov\u00e1ny zm\u011bnou doby p\u0159\u00edjmu potravy, co\u017e ovliv\u0148uje i dal\u0161\u00ed fyziologick\u00e9 procesy v mozku. Choroidn\u00ed plexus tak m\u016f\u017ee b\u00fdt kl\u00ed\u010dov\u00fdm \u201esenzorem\u201c \u017eivotn\u00edho stylu, kter\u00fd propojuje sv\u011bteln\u00e9 a stravovac\u00ed sign\u00e1ly.<\/h6>\n<p>V modern\u00ed spole\u010dnosti je b\u011b\u017en\u00e9, \u017ee lid\u00e9 jed\u00ed v pozdn\u00ed ve\u010dern\u00ed dob\u011b, kdy jsou jejich vnit\u0159n\u00ed hodiny nastaveny na dobu sp\u00e1nku. V\u00fdsledky nov\u00e9 studie nazna\u010duj\u00ed, \u017ee nesoulad mezi sv\u011bteln\u00fdm re\u017eimem a na\u010dasov\u00e1n\u00edm j\u00eddla m\u016f\u017ee v\u00e9st k rozlad\u011bn\u00ed vnit\u0159n\u00edho prost\u0159ed\u00ed mozku, a tedy ke zv\u00fd\u0161en\u00ed rizika metabolick\u00fdch a neurodegenerativn\u00edch onemocn\u011bn\u00ed.<\/p>\n<p>Ve v\u00fdzkumu, kter\u00fd podpo\u0159ila Grantov\u00e1 agentura \u010cR, vyu\u017eili v\u011bdci a v\u011bdkyn\u011b pokro\u010dil\u00e9 molekul\u00e1rn\u011b-biologick\u00e9 metody a pracovali s my\u0161\u00edmi modely. Pokud se my\u0161\u00edm posunulo krmen\u00ed na denn\u00ed dobu, kdy by norm\u00e1ln\u011b spaly, se\u0159\u00eddily se jejich vnit\u0159n\u00ed hodiny v choroidn\u00edm plexu podle \u010dasu p\u0159\u00edjmu potravy rychleji ne\u017e v jin\u00fdch oblastech mozku. \u201e<em>Z\u00e1sadn\u00ed je, \u017ee hodiny v tomto p\u0159\u00edpad\u011b n\u00e1sleduj\u00ed \u010das j\u00eddla, nikoli sv\u011bteln\u00fd cyklus,\u201c<\/em> zd\u016fraz\u0148uje Alena Sumov\u00e1, vedouc\u00ed <a href=\"https:\/\/fgu.cas.cz\/vyzkum-a-laboratore\/vyzkumna-oddeleni\/biologicke-rytmy\/\" target=\"_blank\" rel=\"noopener\"><strong>Odd\u011blen\u00ed biologick\u00fdch rytm\u016f z Fyziologick\u00e9ho \u00fastavu AV \u010cR<\/strong><\/a>. Znamen\u00e1 to, \u017ee biologick\u00e9 hodiny v choroidn\u00edm plexu se synchronizuj\u00ed s nov\u00fdm re\u017eimem v p\u0159\u00edjmu potravy, zat\u00edmco hodiny v jin\u00fdch \u010d\u00e1stech mozku z\u016fst\u00e1vaj\u00ed nastaven\u00e9 podle sv\u011btla.<\/p>\n<p>Mechanismus zahrnuje j\u00eddlem zp\u016fsoben\u00e9 zv\u00fd\u0161en\u00ed hladin inzulinu, gluk\u00f3zy a t\u011blesn\u00e9 teploty, kter\u00e9 p\u0159\u00edmo ovliv\u0148uj\u00ed molekul\u00e1rn\u00ed hodiny. \u201e<em>V\u00fdsledky na\u0161\u00ed studie ukazuj\u00ed, \u017ee choroidn\u00ed plexus je unik\u00e1tn\u00ed mozkovou strukturou, kter\u00e1 dok\u00e1\u017ee p\u0159\u00edmo reagovat jak na sv\u011bteln\u00fd re\u017eim, tak na zm\u011bny v na\u010dasov\u00e1n\u00ed potravy \u2013 a t\u00edm upravovat produkci mozkom\u00ed\u0161n\u00edho moku a dal\u0161\u00ed kl\u00ed\u010dov\u00e9 procesy spojen\u00e9 s ochranou a v\u00fd\u017eivou mozku,\u201c<\/em> vysv\u011btluje Alena Sumov\u00e1.<\/p>\n<p>Ukazuje se, \u017ee choroidn\u00ed plexus je nejen citliv\u00fd na sign\u00e1ly z centr\u00e1ln\u00edch hodin \u0159\u00edzen\u00fdch sv\u011btlem, ale tak\u00e9 dok\u00e1\u017ee rychle p\u0159enastavit sv\u016fj rytmus podle doby p\u0159\u00edjmu potravy. \u201e<em>To m\u016f\u017ee m\u00edt z\u00e1sadn\u00ed dopad na zdrav\u00ed mozku, zejm\u00e9na v souvislosti s modern\u00edm \u017eivotn\u00edm stylem, kdy jsou sv\u011bteln\u00e9 podm\u00ednky a re\u017eim j\u00eddla \u010dasto v nesouladu,\u201c<\/em> dod\u00e1v\u00e1 v\u011bdkyn\u011b.<\/p>\n<p><strong>Odkaz na publikaci:<\/strong><\/p>\n<p>Dockal et al., Cellular and Molecular Life Sciences, 2025, \u201eFeeding regime synchronizes circadian clock in choroid plexus \u2013 insight into a complex mechanism\u201c <a href=\"https:\/\/doi.org\/10.1007\/s00018-025-05798-3\" target=\"_blank\" rel=\"noopener\"><strong>https:\/\/doi.org\/10.1007\/s00018-025-05798-3<\/strong><\/a><\/p>\n<p><strong>(tz-av\u010dr)<\/strong><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Nov\u00fd <\/p>\n","protected":false},"author":2,"featured_media":352853,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[179,174],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2025\/08\/02\/ram-hodiny.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/352852"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=352852"}],"version-history":[{"count":1,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/352852\/revisions"}],"predecessor-version":[{"id":352854,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/352852\/revisions\/352854"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/352853"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=352852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=352852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=352852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}