{"id":344286,"date":"2025-04-30T17:33:31","date_gmt":"2025-04-30T16:33:31","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=344286"},"modified":"2025-04-30T17:33:31","modified_gmt":"2025-04-30T16:33:31","slug":"ceska-republika-naruseni-biologickych-hodin-muze-prispivat-k-porucham-metabolismu","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=344286","title":{"rendered":"\u010cESK\u00c1 REPUBLIKA: Naru\u0161en\u00ed biologick\u00fdch hodin m\u016f\u017ee p\u0159isp\u00edvat k poruch\u00e1m metabolismu"},"content":{"rendered":"
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Ilustra\u010dn\u00ed foto: pixabay<\/figcaption><\/figure>\n

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Nepravideln\u00fd denn\u00ed re\u017eim sv\u011btla a stravov\u00e1n\u00ed m\u016f\u017ee v\u00e9st k z\u00e1va\u017en\u00fdm metabolick\u00fdm poruch\u00e1m, v\u010detn\u011b zhor\u0161en\u00e9 regulace hladin gluk\u00f3zy a zm\u011bn v metabolismu tuk\u016f. To jsou v\u00fdsledky v\u00fdzkumu v\u011bdc\u016f z Fyziologick\u00e9ho \u00fastavu AV \u010cR. Studie byla realizov\u00e1na v projektu CarDia, financovan\u00e9m z programu EXCELES Evropsk\u00e9 unie.<\/h6>\n

\"\"Odborn\u00edci v experimentu vystavili dlouhodob\u011b samice laboratorn\u00edch potkan\u016f st\u00e1l\u00e9mu sv\u011btlu, kter\u00e9 se st\u0159\u00eddalo s krmen\u00edm v nevhodnou denn\u00ed dobu. Chronicky tak naru\u0161ili schopnost jejich centr\u00e1ln\u00edch biologick\u00fdch hodin v mozku regulovat rytmy v t\u011ble. To vedlo k nepravidelnosti sp\u00e1nkov\u00e9ho a reproduk\u010dn\u00edho cyklu a k naru\u0161en\u00ed cirkadi\u00e1nn\u00edch hodin v r\u016fzn\u00fdch tk\u00e1n\u00edch v t\u011ble, v\u010detn\u011b hodin v j\u00e1trech a slinivce.<\/p>\n

N\u00e1sledkem toho se u zkouman\u00fdch zv\u00ed\u0159at zhor\u0161ila regulace hladin gluk\u00f3zy v krvi, kter\u00e1 je rizikov\u00fdm faktorem pro vznik cukrovky. Nav\u00edc byly zji\u0161t\u011bny metabolick\u00e9 zm\u011bny v j\u00e1trech, v\u010detn\u011b hromad\u011bn\u00ed acylkarnitin\u016f (slou\u010denina, kter\u00e1 je zapojen\u00e1 do p\u0159enosu mastn\u00fdch kyselin do mitochondri\u00ed), co\u017e nazna\u010duje poruchu v metabolismu tuk\u016f.<\/p>\n

\u201eNa\u0161e v\u00fdsledky ukazuj\u00ed, \u017ee naru\u0161en\u00ed biologick\u00fdch hodin m\u016f\u017ee m\u00edt negativn\u00ed dopad na metabolick\u00e9 zdrav\u00ed, co\u017e se obzvl\u00e1\u0161t\u011b t\u00fdk\u00e1 osob s nepravideln\u00fdm re\u017eimem, jako jsou pracovn\u00edci ve sm\u011bnn\u00e9m provozu,\u201c<\/em> uvedla autorka studie a vedouc\u00ed Odd\u011blen\u00ed biologick\u00fdch rytm\u016f Alena Sumov\u00e1 z Fyziologick\u00e9ho \u00fastavu AV \u010cR.<\/p>\n

Studie tak\u00e9 upozor\u0148uje na potenci\u00e1ln\u00ed vyu\u017eit\u00ed acylkarnitin\u016f jako biomarker\u016f pro diagnostiku metabolick\u00fdch poruch, kter\u00e9 jsou spojen\u00e9 s naru\u0161en\u00edm cirkadi\u00e1nn\u00edch rytm\u016f. V\u00fdsledky mohou pomoci p\u0159i v\u00fdvoji nov\u00fdch preventivn\u00edch a terapeutick\u00fdch p\u0159\u00edstup\u016f.<\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

\n

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