{"id":335803,"date":"2025-01-29T22:31:16","date_gmt":"2025-01-29T21:31:16","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=335803"},"modified":"2025-01-29T22:33:06","modified_gmt":"2025-01-29T21:33:06","slug":"ceska-republika-cesti-vedci-objevili-novou-metodu-diagnostiky-koznich-infekci-pomoci-vune","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=335803","title":{"rendered":"\u010cESK\u00c1 REPUBLIKA: \u010ce\u0161t\u00ed v\u011bdci objevili novou metodu diagnostiky ko\u017en\u00edch infekc\u00ed"},"content":{"rendered":"
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N\u00e1vrh dermatologick\u00e9 ambulance budoucnosti: l\u00e9ka\u0159 identifikuje patogena pomoc\u00ed mal\u00e9ho detektoru pach\u016f a okam\u017eit\u011b zah\u00e1j\u00ed l\u00e9\u010dbu. Sou\u010d\u00e1st\u00ed prevence re-infekce m\u016f\u017ee b\u00fdt nap\u0159\u00edklad antimykotick\u00e1 l\u00e9\u010dba pro asymptomatick\u00e9ho dom\u00e1c\u00edho mazl\u00ed\u010dka.<\/figcaption><\/figure>\n

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Ko\u017en\u00ed infekce zp\u016fsoben\u00e9 pl\u00edsn\u011bmi, jako jsou myk\u00f3zy nohou, neht\u016f nebo vlasov\u00e9 poko\u017eky, by mohly b\u00fdt brzy diagnostikov\u00e1ny rychleji a p\u0159esn\u011bji d\u00edky v\u00fdzkumu v\u011bdc\u016f z Mikrobiologick\u00e9ho \u00fastavu Akademie v\u011bd \u010cR. Nov\u00fd p\u0159\u00edstup, kter\u00fd vyu\u017e\u00edv\u00e1 anal\u00fdzu t\u011bkav\u00fdch organick\u00fdch l\u00e1tek (volatil\u016f) produkovan\u00fdch patogeny, otev\u00edr\u00e1 cestu k inovativn\u00ed diagnostick\u00e9 metod\u011b. T\u011bkav\u00e9 l\u00e1tky se toti\u017e v mal\u00e9m mno\u017estv\u00ed posl\u00e9ze uvol\u0148uj\u00ed do ovzdu\u0161\u00ed i b\u011bhem infekce na hostiteli, co\u017e p\u0159isp\u00edv\u00e1 k charakteristick\u00e9mu z\u00e1pachu \u201ezapa\u0159en\u00fdch nohou\u201c. V\u00fdzkum publikoval presti\u017en\u00ed \u010dasopis Mycopathologia.<\/h6>\n

\"\"Dermatofyty jsou houby zp\u016fsobuj\u00edc\u00ed ko\u017en\u00ed infekce, kter\u00e9 mohou b\u00fdt zdravotn\u011b i esteticky nep\u0159\u00edjemn\u00e9 a jejich\u017e diagnostika b\u00fdv\u00e1 \u010dasto zdlouhav\u00e1 a komplikovan\u00e1.<\/p>\n

Nov\u00e1 studie vypracovan\u00e1 t\u00fdmem z laborato\u0159e Genetiky a metabolismu hub v Mikrobiologick\u00e9m \u00fastavu AV \u010cR se zam\u011b\u0159ila na anal\u00fdzu spektra t\u011bkav\u00fdch organick\u00fdch l\u00e1tek, tedy chemick\u00fdch l\u00e1tek uvol\u0148ovan\u00fdch do vzduchu, kter\u00e9 r\u016fzn\u00e9 druhy dermatofyt\u016f produkuj\u00ed. V\u00fdzkum vytvo\u0159il z\u00e1klad pro v\u00fdvoj rychlej\u0161\u00edch diagnostick\u00fdch metod, kter\u00e9 by mohly diagnostiku houbov\u00fdch infekc\u00ed z\u00e1sadn\u011b zjednodu\u0161it.<\/p>\n

Diagnostika p\u0159\u00edmo na t\u011ble pomoc\u00ed elektronick\u00e9ho nosu<\/h6>\n

\u201eZjistili jsme, \u017ee r\u016fzn\u00e9 druhy dermatofyt\u016f produkuj\u00ed unik\u00e1tn\u00ed spektra volatil\u016f. Toto pozn\u00e1n\u00ed by mohlo umo\u017enit diagnostiku p\u0159\u00edmo na t\u011ble pacienta bez nutnosti zdlouhav\u00e9 kultivace. L\u00e1tky by mohl detekovat nap\u0159\u00edklad takzvan\u00fd \u201eelektronick\u00fd nos\u201c, za\u0159\u00edzen\u00ed zn\u00e1m\u00e9 z leti\u0161tn\u00edch kontrol, kter\u00e9 dok\u00e1\u017ee zachytit i stopov\u00e1 mno\u017estv\u00ed chemick\u00fdch l\u00e1tek,\u201c<\/em> \u0159\u00edk\u00e1 vedouc\u00ed laborato\u0159e Miroslav Kola\u0159\u00edk.<\/p>\n

\u201eKa\u017ed\u00fd druh dermatofyt\u016f m\u00e1 sv\u016fj specifick\u00fd pachov\u00fd profil. D\u00edky tomu m\u016f\u017eeme nejen rozli\u0161it jednotliv\u00e9 druhy, ale dokonce i kmeny rezistentn\u00ed v\u016f\u010di b\u011b\u017en\u011b pou\u017e\u00edvan\u00fdm antimykotik\u016fm,\u201c<\/em> popisuje prvn\u00ed autorka \u010dl\u00e1nku Lenka Machov\u00e1. Objev by podle n\u00ed mohl v\u00fdrazn\u011b p\u0159isp\u011bt k boji proti rostouc\u00ed rezistenci na l\u00e9\u010diva t\u00edm, \u017ee umo\u017en\u00ed l\u00e9ka\u0159\u016fm c\u00edlen\u011b nasadit spr\u00e1vnou l\u00e9\u010dbu ji\u017e na za\u010d\u00e1tku infekce.<\/p>\n

Tradi\u010dn\u00ed metody, jako jsou mikroskopick\u00e9 vy\u0161et\u0159en\u00ed nebo kultivace vzorku, se pou\u017e\u00edvaj\u00ed jen v ojedin\u011bl\u00fdch p\u0159\u00edpadech a mohou trvat i n\u011bkolik dn\u00ed a\u017e t\u00fdden. V praxi se tak dermatologov\u00e9 \u010dasto spol\u00e9haj\u00ed na symptomy pacienta a vol\u00ed l\u00e9\u010dbu metodou pokusu a omylu. Nejde o jejich nedostate\u010dnou odbornost, ale sp\u00ed\u0161e o absenci rychl\u00fdch a spolehliv\u00fdch diagnostick\u00fdch n\u00e1stroj\u016f.<\/p>\n

\u201eNap\u0159\u00edklad kortikoidy, kter\u00e9 se b\u011b\u017en\u011b pou\u017e\u00edvaj\u00ed k l\u00e9\u010db\u011b z\u00e1n\u011btliv\u00fdch ko\u017en\u00edch onemocn\u011bn\u00ed, mohou u houbov\u00fdch infekc\u00ed probl\u00e9m je\u0161t\u011b zhor\u0161it. Bez rychl\u00e9ho potvrzen\u00ed diagn\u00f3zy je v\u0161ak t\u011b\u017ek\u00e9 zvolit c\u00edlenou l\u00e9\u010dbu,\u201c<\/em> vysv\u011btluje Miroslav Kola\u0159\u00edk.<\/p>\n

P\u0159\u00edstroje pro diagnostiku p\u0159\u00edmo na m\u00edst\u011b<\/h6>\n

Vedouc\u00ed v\u00fdzkumn\u00e9 skupiny Ad\u00e9la Wennrich zd\u016fraz\u0148uje, \u017ee \u201etato metoda m\u00e1 obrovsk\u00fd potenci\u00e1l, ale je nutn\u00e9 ji d\u00e1le technologicky rozvinout. Na\u0161\u00edm c\u00edlem je vytvo\u0159it p\u0159\u00edstroj, kter\u00fd bude pou\u017eiteln\u00fd v klinick\u00e9 praxi, co\u017e by z\u00e1sadn\u011b zrychlilo diagnostiku a zlep\u0161ilo l\u00e9\u010debn\u00e9 postupy\u201c<\/em>.<\/p>\n

Studie nav\u00edc otev\u00edr\u00e1 mo\u017enosti dal\u0161\u00edmu v\u00fdzkumu a v\u00fdvoji p\u0159\u00edstroj\u016f schopn\u00fdch vyu\u017e\u00edt t\u011bkav\u00e9 l\u00e1tky pro diagnostiku p\u0159\u00edmo u pacienta. Podobn\u00e9 p\u0159\u00edstupy by mohly b\u00fdt aplikov\u00e1ny i na dal\u0161\u00ed mikroorganismy, co\u017e zvy\u0161uje v\u00fdznam t\u00e9to inovace nejen v medic\u00edn\u011b, ale i v dal\u0161\u00edch oblastech biotechnologi\u00ed.<\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

 <\/p>\n

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Vizualizace hyf dermatofytu (mod\u0159e) v ko\u017en\u00ed tk\u00e1ni pomoc\u00ed sv\u011bteln\u00e9ho mikroskopu. Autor: R. Dobi\u00e1\u0161.<\/figcaption><\/figure>\n

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\"\"
Typick\u00e9 z\u00e1n\u011btliv\u00e9 lo\u017eisko na p\u0159edlokt\u00ed pacienta naka\u017een\u00e9ho dermatofytem p\u0159enesen\u00fdm z je\u017e\u010d\u00edho dom\u00e1c\u00edho mazl\u00ed\u010dka. Autor: N. Mall\u00e1tov\u00e1.<\/figcaption><\/figure>\n

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\"\"
Ztr\u00e1ta vlas\u016f u d\u011btsk\u00e9ho pacienta zp\u016fsoben\u00e1 dermatofyt\u00f3zou, kter\u00e1 je nej\u010dast\u011bji p\u0159en\u00e1\u0161ena ko\u010dkami. Auto\u0159i: J. Star\u00e1 a M. Sko\u0159epov\u00e1.<\/figcaption><\/figure>\n

 <\/p>\n

\"\"
Klinick\u00fd obraz infekce neht\u016f, jednoho z nej\u010dast\u011bj\u0161\u00edch projev\u016f dermatofyt\u00f3zy. Auto\u0159i: J. Star\u00e1 a M. Sko\u0159epov\u00e1.<\/figcaption><\/figure>\n

 <\/p>\n

\"\"
Rozs\u00e1hl\u00e1 dermatofyt\u00f3za trupu u d\u011btsk\u00e9ho pacienta po kontaktu s naka\u017eenou ko\u010dkou. Auto\u0159i: J. Star\u00e1 a M. Sko\u0159epov\u00e1.<\/figcaption><\/figure>\n
\n

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  Ko\u017en\u00ed <\/p>\n","protected":false},"author":2,"featured_media":335810,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[19,174],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2025\/01\/29\/dermatologicka-ambulance-budoucnosti-ttt.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/335803"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=335803"}],"version-history":[{"count":3,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/335803\/revisions"}],"predecessor-version":[{"id":335813,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/335803\/revisions\/335813"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/335810"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=335803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=335803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=335803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}