{"id":329295,"date":"2024-11-21T14:34:16","date_gmt":"2024-11-21T13:34:16","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=329295"},"modified":"2024-11-21T18:11:05","modified_gmt":"2024-11-21T17:11:05","slug":"z-prvni-ruky-vedci-odhalili-klicovy-protein-pro-vyvoj-nove-generace-antibiotik-ucinnych-proti-odolnym-bakteriim","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=329295","title":{"rendered":"Z PRVN\u00cd RUKY: V\u011bdci odhalili kl\u00ed\u010dov\u00fd protein pro v\u00fdvoj nov\u00e9 generace antibiotik \u00fa\u010dinn\u00fdch proti odoln\u00fdm bakteri\u00edm"},"content":{"rendered":"<h6><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-243085 alignleft\" src=\"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-300x80.png\" alt=\"\" width=\"300\" height=\"80\" srcset=\"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-300x80.png 300w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-768x206.png 768w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1024x275.png 1024w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1331x357.png 1331w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2021\/12\/19\/akademie-v\u011bd-av-cr-logo-1801x483.png 1801w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>Bakterie rezistentn\u00ed v\u016f\u010di antibiotik\u016fm p\u0159edstavuj\u00ed glob\u00e1ln\u00ed hrozbu pro ve\u0159ejnost. Tato rezistence zt\u011b\u017euje l\u00e9\u010dbu nemoc\u00ed, jako je nap\u0159\u00edklad tuberkul\u00f3za nebo z\u00e1pal plic. V\u011bdci z Mikrobiologick\u00e9ho \u00fastavu AV \u010cR ve spolupr\u00e1ci s Biotechnologick\u00fdm \u00fastavem AV \u010cR a CEITEC Masarykovy univerzity odhalili nov\u00fd mechanismus, kter\u00fd by mohl vydl\u00e1\u017edit cestu k budouc\u00ed l\u00e9\u010db\u011b bakteri\u00e1ln\u00edch onemocn\u011bn\u00ed. V\u00fdsledky zve\u0159ejnil \u010dasopis <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/jb.00066-24\" target=\"_blank\" rel=\"noopener\"><strong>Journal of Bacteriology<\/strong><\/a>.<\/h6>\n<p>Schopnost odol\u00e1vat antibiotik\u016fm je zak\u00f3dov\u00e1na v bakteri\u00e1ln\u00ed DNA. Bakterie sv\u00e9 genetick\u00e9 instrukce \u201e\u010dtou\u201c pomoc\u00ed procesu zvan\u00e9ho genov\u00e1 exprese a na z\u00e1klad\u011b informace v DNA vytv\u00e1\u0159ej\u00ed proteiny. Tyto proteiny jsou jako stavebn\u00ed kameny, kter\u00e9 bakterie pot\u0159ebuj\u00ed k r\u016fstu, mno\u017een\u00ed a reakci na stresov\u00e9 faktory, jak\u00fdmi jsou kup\u0159\u00edkladu pr\u00e1v\u011b antibiotika.<\/p>\n<h6>Nov\u00fd c\u00edl antibakteri\u00e1ln\u00ed terapie<\/h6>\n<p>B\u011bhem p\u011btilet\u00e9ho v\u00fdzkumu v\u011bdci zjistili, \u017ee c\u00edlem nov\u00fdch terapi\u00ed proti rezistentn\u00edm bakteri\u00edm by mohl b\u00fdt protein zvan\u00fd MoaB2. \u201e<em>Zjistili jsme, \u017ee tento protein interaguje s kl\u00ed\u010dov\u00fdm proteinem zvan\u00fdm Sigma-A, kter\u00fd \u0159\u00edd\u00ed, jak bakterie zap\u00ednaj\u00ed sv\u00e9 geny. MoaB2 ovliv\u0148uje dostupnost a stabilitu Sigmy-A a t\u00edm pak produkci b\u00edlkovin v bakterii,\u201c<\/em> \u0159\u00edk\u00e1 vedouc\u00ed v\u00fdzkumn\u00e9 skupiny Libor Kr\u00e1sn\u00fd z Mikrobiologick\u00e9ho \u00fastavu AV \u010cR.<\/p>\n<p>Bez protein\u016f Sigma-A bakterie ztr\u00e1c\u00ed schopnost r\u016fst, mno\u017eit se. Interakce mezi Sigma-A a MoaB2 se tak st\u00e1v\u00e1 atraktivn\u00edm c\u00edlem pro v\u00fdvoj nov\u00e9 generace l\u00e9k\u016f. \u201eUzamknut\u00ed\u201c Sigma-A v interakci s MoaB2 m\u016f\u017ee b\u00fdt nov\u00fdm sm\u011brem pro budouc\u00ed antibakteri\u00e1ln\u00ed terapie.<\/p>\n<p>Objev odhaluje mo\u017enosti pro v\u00fdvoj nov\u00fdch l\u00e9k\u016f, kter\u00e9 by mohly p\u0159in\u00e9st z\u00e1sadn\u00ed zm\u011bny v l\u00e9\u010db\u011b infekc\u00ed zp\u016fsoben\u00fdch rezistentn\u00edmi bakteriemi. To by m\u011blo \u0161irok\u00fd dopad na zdravotn\u00ed p\u00e9\u010di, zejm\u00e9na v oblastech, kde selh\u00e1vaj\u00ed tradi\u010dn\u00ed antibiotick\u00e9 terapie.<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Model funk\u010dn\u00ed interakce mezi MoaB2, Sigma-A (v obr\u00e1zku ozna\u010deno jako \u03c3A) a RNA polymer\u00e1zou v mykobakteri\u00e1ln\u00ed bu\u0148ce. Vazba MoaB2 na Sigma-A m\u00e1 potenci\u00e1l sn\u00ed\u017eit dostupnost Sigma-A v bu\u0148ce, co\u017e pravd\u011bpodobn\u011b ovliv\u0148uje transkripci t\u00edm, \u017ee MoaB2 sout\u011b\u017e\u00ed s RNA polymer\u00e1zou o Sigma-A. Sigma-A nav\u00e1zan\u00fd na MoaB2 nen\u00ed schopen se v\u00e1zat na RNA polymer\u00e1zu. V\u00fdsledky studie uk\u00e1zaly, \u017ee MoaB2 m\u016f\u017ee interakc\u00ed se Sigma-A pozitivn\u011b ovlivnit stabilitu Sigma-A.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Text a foto: (tz-av\u010dr)<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-329296 size-full\" src=\"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein.jpg\" alt=\"\" width=\"920\" height=\"911\" srcset=\"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein.jpg 920w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein-300x297.jpg 300w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein-150x150.jpg 150w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein-768x760.jpg 768w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein-361x357.jpg 361w, https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/klicovy-protein-488x483.jpg 488w\" sizes=\"(max-width: 920px) 100vw, 920px\" \/><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6>Informujeme:<\/h6>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=328865\" target=\"_blank\" rel=\"noopener\">V\u00fddaje na p\u0159\u00edsp\u011bvek na bydlen\u00ed vzrostly loni na dvojn\u00e1sobek<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329293\" target=\"_blank\" rel=\"noopener\">P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 21. listopadu 2024<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329275\" target=\"_blank\" rel=\"noopener\">Usnesen\u00ed Sn\u011bmu \u010cMKOS: V\u00fdzva premi\u00e9rovi, vl\u00e1d\u011b a Sen\u00e1tu \u010cR<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329217\" target=\"_blank\" rel=\"noopener\">\u010ceskobud\u011bjovi\u010dt\u00ed v\u011bdci objevili nov\u00fd ob\u0159\u00ed virus v \u0159\u00edmovsk\u00e9 n\u00e1dr\u017ei. Napad\u00e1 sladkovodn\u00ed \u0159asy a dostal jm\u00e9no Budvirus<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329209\" target=\"_blank\" rel=\"noopener\">P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 20. listopadu 2024<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329110\" target=\"_blank\" rel=\"noopener\">V\u00fdstraha meteorolog\u016f<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329159\" target=\"_blank\" rel=\"noopener\">Jak\u00e9 bude po\u010das\u00ed<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329106\" target=\"_blank\" rel=\"noopener\">Pod\u00edl penzijn\u00edch n\u00e1rok\u016f na HDP za rok 2023 se m\u00edrn\u011b sn\u00ed\u017eil<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329065\" target=\"_blank\" rel=\"noopener\">Rady spot\u0159ebitel\u016fm pro bezpe\u010dn\u011bj\u0161\u00ed nakupov\u00e1n\u00ed, nejen o Black Friday<\/a><\/h4>\n<h4 class=\"entry-title\"><a href=\"https:\/\/zakrasnejsivimperk.cz\/?p=329061\" target=\"_blank\" rel=\"noopener\">P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 19. listopadu 2024<\/a><\/h4>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bakterie rezistentn\u00ed <\/p>\n","protected":false},"author":2,"featured_media":329299,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[70],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/20\/z-ruky-vedci.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/329295"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=329295"}],"version-history":[{"count":2,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/329295\/revisions"}],"predecessor-version":[{"id":329355,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/329295\/revisions\/329355"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/329299"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=329295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=329295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=329295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}