{"id":327925,"date":"2024-11-07T19:53:40","date_gmt":"2024-11-07T18:53:40","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=327925"},"modified":"2024-11-07T19:53:40","modified_gmt":"2024-11-07T18:53:40","slug":"z-prvni-ruky-antidiabetika-umi-pomoci-i-s-onemocnenimi-srdce-a-jater","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=327925","title":{"rendered":"Z PRVN\u00cd RUKY: Antidiabetika um\u00ed pomoci i s onemocn\u011bn\u00edmi srdce a jater"},"content":{"rendered":"
\"\"Glifloziny jsou antidiabetika, jejich\u017e p\u0159\u00edzniv\u00e9 \u00fa\u010dinky se projevuj\u00ed nejen p\u0159i l\u00e9\u010db\u011b diabetik\u016f. T\u00fdm z Fyziologick\u00e9ho \u00fastavu AV \u010cR se zam\u011b\u0159il na to, jak \u00fa\u010dinkuj\u00ed u potkan\u016f v p\u0159\u00edpad\u011b kombinovan\u00e9ho onemocn\u011bn\u00ed jater a srdce. V\u00fdsledkem bylo krom\u011b sn\u00ed\u017een\u00ed p\u0159\u00edr\u016fstku t\u011blesn\u00e9 hmotnosti a \u00fa\u010dinn\u011bj\u0161\u00ed reakce organismu na zv\u00fd\u0161en\u00fd p\u0159\u00edjem tuk\u016f tak\u00e9 zlep\u0161en\u00ed \u0159ady metabolick\u00fdch parametr\u016f a funkce srdce. T\u00fdm se chce d\u00e1le zam\u011b\u0159it na studium rozd\u00edl\u016f \u00fa\u010dink\u016f t\u011bchto antidiabetik v z\u00e1vislosti na pohlav\u00ed a v\u011bku jedince.<\/h6>\n

\u0158ada pacient\u016f, a\u0165 u\u017e diabetik\u016f nebo nediabetik\u016f, p\u0159ich\u00e1z\u00ed do nemocnice s kombinac\u00ed r\u016fzn\u00fdch chorob. V posledn\u00ed dob\u011b se zjistilo, \u017ee glifloziny maj\u00ed p\u0159\u00edzniv\u00e9 \u00fa\u010dinky p\u0159i srde\u010dn\u00edm selh\u00e1n\u00ed a tak\u00e9 na po\u0161kozen\u00e1 j\u00e1tra. T\u00fdm Ivany Van\u011b\u010dkov\u00e9 z Fyziologick\u00e9ho \u00fastavu AV \u010cR proto ke studiu zvolil model kombinovan\u00e9ho onemocn\u011bn\u00ed, jatern\u00edho a srde\u010dn\u00edho. V\u011bdci se konkr\u00e9tn\u011b soust\u0159edili na empagliflozin a v experimentu zji\u0161\u0165ovali, jak je na takovou kombinaci chorob dan\u00fd l\u00e9k \u00fa\u010dinn\u00fd.<\/p>\n

\u201eZkoumali jsme kombinovan\u00e9 jatern\u00ed a srde\u010dn\u00ed selh\u00e1n\u00ed vyvolan\u00e9 vysokotukovou dietou u hypertenzn\u00edch laboratorn\u00edch potkan\u016f. Zjistili jsme, \u017ee empagliflozin sn\u00ed\u017eil p\u0159\u00edr\u016fstek t\u011blesn\u00e9 hmotnosti a zlep\u0161il citlivost organismu na gluk\u00f3zu. Mimoto se zlep\u0161ilo n\u011bkolik metabolick\u00fdch parametr\u016f: plazmatick\u00fd inzulin, kyselina mo\u010dov\u00e1 a HDL cholesterol,\u201c<\/em> popisuje Ivana Van\u011b\u010dkov\u00e1.<\/p>\n

Nap\u0159\u00edklad zv\u00fd\u0161en\u00e1 hladina kyseliny mo\u010dov\u00e9 vede k r\u016fzn\u00fdm zdravotn\u00edm pot\u00ed\u017e\u00edm, z nich\u017e nejzn\u00e1m\u011bj\u0161\u00ed je dna. Pacienti se zv\u00fd\u0161enou koncentrac\u00ed kyseliny mo\u010dov\u00e9 obecn\u011b jsou p\u0159i porovn\u00e1n\u00ed se zdrav\u00fdmi lidmi vystaveni v\u00fdrazn\u011b vy\u0161\u0161\u00edmu kardiovaskul\u00e1rn\u00edmu riziku. Proto i tento \u201evedlej\u0161\u00ed\u201c pozitivn\u00ed \u00fa\u010dinek l\u00e9ku krom\u011b hypoglykemick\u00e9ho m\u016f\u017ee b\u00fdt pro nemocn\u00e9ho \u010dlov\u011bka v\u00fdhodn\u00fd.<\/p>\n

\u0160ikovn\u00fd empagliflozin<\/h6>\n

V j\u00e1trech empagliflozin sn\u00ed\u017eil akumulaci lipid\u016f (tuk\u016f) a n\u011bkter\u00e9 markery z\u00e1n\u011btu. Krom\u011b toho pod\u00e1v\u00e1n\u00ed empagliflozinu zlep\u0161ilo srde\u010dn\u00ed funkci (systolickou, diastolickou a pumpovac\u00ed), a\u010dkoli u modelu nesni\u017eoval krevn\u00ed tlak.<\/p>\n

Z\u00edskan\u00e1 data prok\u00e1zala, \u017ee po\u0161kozen\u00ed funkce jater a srdce vyvolan\u00e1 vysokotukou dietou je mo\u017en\u00e9 potla\u010dit pod\u00e1v\u00e1n\u00edm empagliflozinu, a nazna\u010duj\u00ed, \u017ee ochrana jater (hepatoprotekce) hraje rozhoduj\u00edc\u00ed roli v p\u0159\u00edzniv\u00fdch \u00fa\u010dinc\u00edch empagliflozinu.<\/p>\n

V\u00fdsledky o p\u016fsoben\u00ed gliflozin\u016f p\u0159i kombinovan\u00fdch onemocn\u011bn\u00edch org\u00e1n\u016f tak mohou v\u00fdznamn\u011b napomoci k \u00fa\u010dinn\u011bj\u0161\u00ed l\u00e9\u010db\u011b pacient\u016f s v\u00edce\u010detn\u00fdmi onemocn\u011bn\u00edmi.<\/p>\n

\u201eGlifloziny jsou v kombinaci s minim\u00e1ln\u00edm mno\u017estv\u00edm ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f jedny z nejl\u00e9pe hodnocen\u00fdch skupin l\u00e9k\u016f v posledn\u00edch 10\u201320 letech,\u201c \u0159\u00edk\u00e1 Ivana Van\u011b\u010dkov\u00e1. \u201eMy se sna\u017e\u00edme soubor znalost\u00ed o t\u011bchto l\u00e9c\u00edch roz\u0161\u00ed\u0159it o studium mechanism\u016f, jak\u00fdm zp\u016fsobem v organismu funguj\u00ed. Velkou neprob\u00e1danou oblast\u00ed jsou pohlavn\u011b a v\u011bkov\u011b z\u00e1visl\u00e9 rozd\u00edly v jejich \u00fa\u010dinc\u00edch, kter\u00fdmi se v sou\u010dasnosti a doufejme i v budoucnosti chceme zab\u00fdvat,\u201c<\/em> dod\u00e1v\u00e1 v\u011bdkyn\u011b.<\/p>\n

Glifloziny zn\u00e1me u\u017e 200 let, prvn\u00ed byly z jablo\u0148ov\u00e9 k\u016fry<\/p>\n

Glifloziny jsou inhibitory sod\u00edko-gluk\u00f3zov\u00e9ho transport\u00e9ru typu 2, jejich\u017e p\u016fsoben\u00edm se vylu\u010duje zv\u00fd\u0161en\u00e9 mno\u017estv\u00ed gluk\u00f3zy a sod\u00edku. Jejich historie sah\u00e1 u\u017e do prvn\u00ed poloviny 19. stolet\u00ed \u2013 tehdy byl objeven florizin, kter\u00fd byl extrahov\u00e1n z k\u016fry jablon\u011b.<\/p>\n

Prvn\u00ed syntetick\u00fd deriv\u00e1t florizinu \u2013 dapagliflozin \u2013 testovali experti u diabetick\u00fdch pacient\u016f p\u0159ed v\u00edce ne\u017e 15 lety. P\u0159i velk\u00fdch klinick\u00fdch studi\u00edch se zkoumaly i dal\u0161\u00ed l\u00e1tky z t\u00e9to skupiny, empagliflozin \u010di canagliflozin, a zjistilo se, \u017ee maj\u00ed kardio- a renoprotektivn\u00ed \u00fa\u010dinky nejen u diabetik\u016f, ale i u nediabetick\u00fdch pacient\u016f. Pozd\u011bj\u0161\u00ed studie uk\u00e1zaly, \u017ee empagliflozin a dal\u0161\u00ed l\u00e9\u010diva maj\u00ed nav\u00edc \u0159adu metabolick\u00fdch \u00fa\u010dink\u016f.<\/p>\n

(tz-av\u010dr)<\/strong><\/p>\n

\n

 <\/p>\n

Informujeme:<\/h6>\n

Z\u00e1jem o burzy \u0161kol stoup\u00e1, rodi\u010de i \u017e\u00e1ci se intenzivn\u011b zaj\u00edmaj\u00ed o v\u00fdb\u011br st\u0159edn\u00ed \u0161koly<\/a><\/h4>\n

Nejv\u00edce rostly tr\u017eby v internetov\u00fdch obchodech<\/a><\/h4>\n

P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 7. listopadu 2024<\/a><\/h4>\n

MF DNES \u2013 Pro\u010d je dnes m\u00e1slo luxusn\u00ed potravina<\/a><\/h4>\n

Lesy \u010cR se Spr\u00e1vou \u017eeleznic cht\u011bj\u00ed urychlit p\u0159\u00edpravu staveb i budov\u00e1n\u00ed strategick\u00e9 infrastruktury<\/a><\/h4>\n

Stavebn\u00ed produkce v z\u00e1\u0159\u00ed klesla<\/a><\/h4>\n

Pr\u016fmyslov\u00e1 produkce v\u202fz\u00e1\u0159\u00ed meziro\u010dn\u011b m\u00edrn\u011b vzrostla<\/a><\/h4>\n

P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 6. listopadu 2024<\/a><\/h4>\n

Z PRVN\u00cd RUKY: \u00da\u0159ad pr\u00e1ce zve\u0159ejnil seznam pobo\u010dek ke zru\u0161en\u00ed<\/a><\/h4>\n

Podzimn\u00ed pr\u00e1zdniny vytvo\u0159ily um\u011bl\u00fd pokles v po\u010dtech hl\u00e1\u0161en\u00fdch respira\u010dn\u00edch infekc\u00ed<\/a><\/h4>\n

P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 5. listopadu 2024<\/a><\/h4>\n

Kl\u00ed\u010dov\u00e9 rysy v\u00fdvoje hlavy obratlovc\u016f maj\u00ed sv\u016fj p\u016fvod u spole\u010dn\u00e9ho p\u0159edka<\/a><\/h4>\n

Cizinci \u017eij\u00edc\u00ed v \u010cesku netvo\u0159\u00ed homogenn\u00ed skupinu<\/a><\/h4>\n

V Jiho\u010desk\u00e9m kraji bylo k 44. t\u00fddnu potvrzeno 3 062 p\u0159\u00edpad\u016f \u010dern\u00e9ho ka\u0161le, v minul\u00e9m t\u00fddnu p\u0159ibylo 23 nov\u00fdch p\u0159\u00edpad\u016f<\/a><\/h4>\n

P\u0158E\u010cT\u011aTE SI U N\u00c1S: Den\u00edk Metro \u2013 4. listopadu 2024<\/a><\/h4>\n

Ch\u0159est z na\u0161ich pol\u00ed \u010cech\u016fm chutn\u00e1. Letos ho \u0161lo do obchod\u016f 182 tun, nejlep\u0161\u00ed prodejci z\u00edskali ocen\u011bn\u00ed<\/a><\/h4>\n

Potravin\u00e1\u0159sk\u00e1 inspekce zjistila dal\u0161\u00ed produkt s obsahem muscimolu \u2013 halucinogenu z muchom\u016frky \u010derven\u00e9<\/a><\/h4>\n

Plynu je v tuzemsk\u00fdch z\u00e1sobn\u00edc\u00edch p\u0159ed zimou dostatek. Napln\u011bny jsou z 93 procent<\/a><\/h4>\n

\u201eUk\u00e1zat lidem faktury \u2013 to maj\u00ed zak\u00e1z\u00e1no.\u201c Pravda o drah\u00e9m m\u00e1sle p\u0159\u00edmo z bran\u017ee<\/a><\/h4>\n
\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Glifloziny jsou <\/p>\n","protected":false},"author":2,"featured_media":327926,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[70],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/11\/07\/z-ruky-avcr.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/327925"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=327925"}],"version-history":[{"count":1,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/327925\/revisions"}],"predecessor-version":[{"id":327927,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/327925\/revisions\/327927"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/327926"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=327925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=327925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=327925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}