{"id":323892,"date":"2024-10-05T18:58:01","date_gmt":"2024-10-05T17:58:01","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=323892"},"modified":"2024-10-05T18:58:01","modified_gmt":"2024-10-05T17:58:01","slug":"ceska-republika-nove-objevene-regeneracni-bunky-mohou-zlepsit-hojeni-ran","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=323892","title":{"rendered":"\u010cESK\u00c1 REPUBLIKA: Nov\u011b objeven\u00e9 regenera\u010dn\u00ed bu\u0148ky mohou zlep\u0161it hojen\u00ed ran"},"content":{"rendered":"

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R\u00e1na se m\u016f\u017ee zahojit bez jizev, pokud jsou p\u0159\u00edtomny regenera\u010dn\u00ed inicia\u010dn\u00ed bu\u0148ky (RIC). Tento z\u00e1v\u011br publikovali v\u011bdci z Biotechnologick\u00e9ho \u00fastavu Akademie v\u011bd \u010cR a 1. l\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy v centru BIOCEV v presti\u017en\u00edm mezin\u00e1rodn\u00edm \u010dasopise Genome Biology. Objev m\u016f\u017ee v budoucnu pomoci v l\u00e9\u010db\u011b onkologick\u00fdch onemocn\u011bn\u00ed.<\/h6>\n

\"\"Embrya se hoj\u00ed typicky bez jizev a mohou dokonce regenerovat chyb\u011bj\u00edc\u00ed \u010d\u00e1sti t\u011bla. Schopnost hojit se, ani\u017e by se utvo\u0159ily jizvy, maj\u00ed i lid\u00e9, resp. nenarozen\u00e9 d\u011bti. N\u011bkter\u00e9 korek\u010dn\u00ed operace se proto prov\u00e1d\u011bj\u00ed je\u0161t\u011b v d\u011bloze matky, aby se zp\u016fsobilost k hojen\u00ed vyu\u017eila. Pro p\u0159e\u017eit\u00ed a spr\u00e1vn\u00fd v\u00fdvoj je pravd\u011bpodobn\u011b rozhoduj\u00edc\u00ed rychl\u00e9 uzav\u0159en\u00ed r\u00e1ny.<\/p>\n

V pozd\u011bj\u0161\u00edm v\u011bku se tato kompetence ztr\u00e1c\u00ed a nahrazuje ji tvorba jizev. Nalezen\u00ed p\u0159\u00ed\u010diny, mo\u017enost obnovy hojen\u00ed bez jizev a schopnosti regenerace ztracen\u00fdch \u010d\u00e1st\u00ed t\u011bla jsou v sou\u010dasnosti velmi atraktivn\u00ed oblast\u00ed modern\u00edho zdravotnictv\u00ed.<\/p>\n

Poran\u011bn\u00ed spou\u0161t\u00ed tvorbu regenera\u010dn\u00edch bun\u011bk<\/h6>\n

Vhodn\u00fdm modelem jsou pulci \u017eab v ran\u00fdch stadi\u00edch v\u00fdvinu, proto\u017ee rychle a efektivn\u011b regeneruj\u00ed amputovan\u00fd ocas. B\u011bhem v\u00fdvoje na n\u011bkolik dn\u00ed schopnost hojen\u00ed ztrat\u00ed, ale pot\u00e9 ji op\u011bt z\u00edskaj\u00ed, co\u017e je vynikaj\u00edc\u00ed modelov\u00fd syst\u00e9m pro studium hojen\u00ed.<\/p>\n

Pomoc\u00ed pokro\u010dil\u00fdch technologi\u00ed, v\u010detn\u011b profilov\u00e1n\u00ed jednotliv\u00fdch bun\u011bk, t\u00fdm z Biotechnologick\u00e9ho \u00fastavu AV \u010cR a 1. l\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy v centru BIOCEV objevil bu\u0148ky, kter\u00e9 se vytv\u00e1\u0159ej\u00ed v reakci na poran\u011bn\u00ed a n\u00e1sledn\u011b migruj\u00ed na povrch r\u00e1ny. Tam pak organizuj\u00ed dal\u0161\u00ed bu\u0148ky, aby chyb\u011bj\u00edc\u00ed tk\u00e1\u0148 regenerovaly. Kdy\u017e svoji \u00falohu spln\u00ed, mizej\u00ed.<\/p>\n

T\u00fdm odborn\u00edk\u016f je nazval RIC \u2013 regenera\u010dn\u00edmi inicia\u010dn\u00edmi bu\u0148kami. RIC se objevuj\u00ed pouze v tk\u00e1n\u00edch s regenera\u010dn\u00ed schopnost\u00ed, pokud jsou fyzicky odstran\u011bny, tato schopnost se ztrat\u00ed a vznikne jizva.<\/p>\n

\u201eNyn\u00ed pokra\u010dujeme v charakterizaci RIC, abychom mohli vyvinout l\u00e9\u010debn\u00e9 postupy, kter\u00e9 je v poran\u011bn\u00fdch tk\u00e1n\u00edch aktivuj\u00ed, navod\u00ed tak hojen\u00ed bez jizev a umo\u017en\u00ed regeneraci tk\u00e1n\u00ed, je\u017e by za norm\u00e1ln\u00edch okolnost\u00ed jizvu vytvo\u0159ily,\u201c<\/em> \u0159\u00edk\u00e1 hlavn\u00ed autor publikace Radek \u0160indelka z Laborato\u0159e genov\u00e9 exprese Biotechnologick\u00e9ho \u00fastavu AV \u010cR.<\/p>\n

Jak dlouho bude v\u00fdvoj l\u00e9\u010dby trvat, je t\u011b\u017ek\u00e9 odhadnout.<\/p>\n

Tento projekt byl podpo\u0159en Grantovou agenturou \u010cR, Agenturou pro zdravotnick\u00fd v\u00fdzkum \u010cR a N\u00e1rodn\u00edm \u00fastavem pro v\u00fdzkum rakoviny.<\/p>\n

Odkaz na publikaci: https:\/\/doi.org\/10.1186\/s13059-024-03396-3<\/strong><\/a><\/p>\n

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Text a foto: (tz-av\u010dr)<\/strong><\/p>\n

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  R\u00e1na <\/p>\n","protected":false},"author":2,"featured_media":323897,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[19],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2024\/10\/01\/Series019_ProjMax001.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/323892"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=323892"}],"version-history":[{"count":1,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/323892\/revisions"}],"predecessor-version":[{"id":323899,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/323892\/revisions\/323899"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/323897"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=323892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=323892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=323892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}