{"id":273181,"date":"2023-02-15T13:43:20","date_gmt":"2023-02-15T12:43:20","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=273181"},"modified":"2023-02-15T13:45:04","modified_gmt":"2023-02-15T12:45:04","slug":"veda-neni-nuda-vedci-objevili-vzacne-protilatky-ktere-blokuji-vsechny-varianty-sars-cov-2","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=273181","title":{"rendered":"V\u011aDA NEN\u00cd NUDA: V\u011bdci objevili vz\u00e1cn\u00e9 protil\u00e1tky, kter\u00e9 blokuj\u00ed v\u0161echny dosud zn\u00e1m\u00e9 varianty SARS-CoV-2"},"content":{"rendered":"

\"\"<\/p>\n

 <\/p>\n

V\u00edce ne\u017e deset milion\u016f sekvenc\u00ed koronaviru SARS-CoV-2 musel prozkoumat mezin\u00e1rodn\u00ed t\u00fdm v\u011bdc\u016f, aby na\u0161el univerz\u00e1ln\u00ed slabiny koronavir\u016f, kter\u00e9 se nem\u011bn\u00ed ani s \u010dast\u00fdmi mutacemi a vznikem nov\u00fdch variant. Anal\u00fdzou vzork\u016f od pacient\u016f se pak poda\u0159ilo odhalit vz\u00e1cn\u00e9 protil\u00e1tky, kter\u00e9 blokuj\u00ed v\u0161echny dosud zn\u00e1m\u00e9 varianty SARS-CoV-2, ale i ostatn\u00ed lidsk\u00e9 koronaviry, a jsou tak p\u0159ipraveny i na dal\u0161\u00ed mo\u017en\u00e9 budouc\u00ed mutace.<\/h6>\n

\"\"Na v\u00fdvoji protil\u00e1tek se pod\u00edleli v\u011bdci z Biologick\u00e9ho centra Akademie v\u011bd \u010cR, \u010cesk\u00e9ho centra pro fenogenomiku \u00dastavu molekul\u00e1rn\u00ed genetiky AV \u010cR a P\u0159\u00edrodov\u011bdeck\u00e9 fakulty Masarykovy univerzity. Objev byl zve\u0159ejn\u011bn\u00fd na konci ledna v \u010dasopise Science Immunology.<\/p>\n

S pokra\u010duj\u00edc\u00ed pandemi\u00ed COVID-19 se vyv\u00edj\u00ed i virus SARS-CoV-2. Vznikaj\u00edc\u00ed varianty mohou m\u00edt nov\u00e9 vlastnosti, d\u00edky nim\u017e se vyh\u00fdbaj\u00ed na\u0161emu imunitn\u00edmu syst\u00e9mu l\u00e9pe ne\u017e jejich p\u0159edch\u016fdci. To sni\u017euje \u00fa\u010dinnost o\u010dkov\u00e1n\u00ed a protektivn\u00edch protil\u00e1tek, proto je pot\u0159eba pokra\u010dovat ve v\u00fdvoji nov\u00fdch generac\u00ed vakc\u00edn a l\u00e9k\u016f. \u0160v\u00fdcar\u0161t\u00ed v\u011bdci z Biomedic\u00ednsk\u00e9ho v\u00fdzkumn\u00e9ho \u00fastavu v Bellinzon\u011b (Institute for Research in Biomedicine) spole\u010dn\u011b s americk\u00fdmi a \u010desk\u00fdmi spolupracovn\u00edky k tomuto probl\u00e9mu p\u0159istoupili tak, \u017ee se zam\u011b\u0159ili na hled\u00e1n\u00ed t\u011bch \u010d\u00e1st\u00ed viru, kter\u00e9 se p\u0159i evoluci nem\u011bn\u00ed a kter\u00e9 jsou z\u00e1rove\u0148 citliv\u00e9 v\u016f\u010di protil\u00e1tk\u00e1m. Na koronaviru na\u0161li 15 takov\u00fdch univerz\u00e1ln\u00edch a vysoce zachovan\u00fdch oblast\u00ed, kde virus v\u016fbec nemutuje.<\/p>\n

Anal\u00fdzou vzork\u016f od pacient\u016f s COVID-19 na\u0161li v\u011bdci pomoc\u00ed nov\u011b vyvinut\u00e9 metody velmi vz\u00e1cn\u00e9 protil\u00e1tky, specifick\u00e9 pro v\u0161ech 15 t\u011bchto konzervovan\u00fdch oblast\u00ed, kter\u00e9 dok\u00e1\u017e\u00ed blokovat virus. \u201eTato m\u00edsta jsou stejn\u00e1 u v\u0161ech variant SARS-CoV-2 i u v\u0161ech ostatn\u00edch koronavir\u016f. Virus tam nem\u016f\u017ee mutovat. Kdy\u017e se tyto nov\u011b objeven\u00e9 protil\u00e1tky nav\u00e1\u017eou na spikov\u00fd protein koronaviru, zp\u016fsob\u00ed to zm\u011bny v jeho struktu\u0159e, a virus se tak nedok\u00e1\u017ee v\u00e1zat na receptor na povrchu hostitelsk\u00e9 bu\u0148ky,\u201c<\/em> vysv\u011btluje Daniel R\u016f\u017eek z Parazitologick\u00e9ho \u00fastavu Biologick\u00e9ho centra AV \u010cR. P\u0159i t\u00e9to studii R\u016f\u017ek\u016fv t\u00fdm \u00fasp\u011b\u0161n\u011b testoval protil\u00e1tky na bun\u011b\u010dn\u00fdch kultur\u00e1ch a na speci\u00e1ln\u00edch laboratorn\u00edch my\u0161\u00edch citliv\u00fdch na infekci virem SARS-CoV-2. \u201eV laboratorn\u00edch experimentech jsme potvrdili, \u017ee protil\u00e1tky blokuj\u00ed virovou infekci a chr\u00e1n\u00ed p\u0159ed onemocn\u011bn\u00edm, a to i v nejnov\u011bj\u0161\u00edch variant\u00e1ch. Protil\u00e1tky jsou nyn\u00ed p\u0159ipraveny pro klinickou studii,\u201c<\/em> \u0159\u00edk\u00e1 dal\u0161\u00ed z autor\u016f studie, Martin Palus z Parazitologick\u00e9ho \u00fastavu Biologick\u00e9ho centra AV \u010cR.<\/p>\n

Na charakterizaci \u00fa\u010dinku protil\u00e1tek se pod\u00edleli i v\u011bdci z \u010cesk\u00e9ho centra pro fenogenomiku \u00dastavu molekul\u00e1rn\u00ed genetiky AV \u010cR a centra BIOCEV, kte\u0159\u00ed vytvo\u0159ili speci\u00e1ln\u00ed my\u0161i modeluj\u00edc\u00ed infekci Covid-19 v plic\u00edch.<\/p>\n

Se \u0161v\u00fdcarsk\u00fdmi v\u011bdci \u010ce\u0161i spolupracovali u\u017e p\u0159ed dv\u011bma lety na v\u00fdvoji bispecifick\u00e9 protil\u00e1tky proti koronaviru, kter\u00e1 u\u017e vstoupila do klinick\u00e9ho testov\u00e1n\u00ed. S v\u00fdskytem varianty omikron se ale uk\u00e1zalo, \u017ee proti t\u00e9to variant\u011b nefunguje. I d\u00edky tomuto zklam\u00e1n\u00ed t\u00fdm vylep\u0161il sv\u016fj p\u016fvodn\u00ed koncept a p\u0159ipravil novou generaci slibn\u00fdch protil\u00e1tek. \u201eJe pravd\u011bpodobn\u00e9, \u017ee se objev\u00ed nov\u00e9 koronaviry. Na\u0161e v\u00fdsledky nazna\u010duj\u00ed, \u017ee u\u017e je mo\u017en\u00e9 vyvinout protiopat\u0159en\u00ed, kter\u00e1 jsou \u0161iroce \u00fa\u010dinn\u00e1 proti sou\u010dasn\u00fdm i budouc\u00edm koronavir\u016fm,\u201c<\/em> \u0159ekl Davide Robbiani, hlavn\u00ed autor objevu a \u0159editel Biomedic\u00ednsk\u00e9ho v\u00fdzkumn\u00e9ho \u00fastavu v Bellinzon\u011b.<\/p>\n

 <\/p>\n

Text a foto: (tz-av\u010dr)<\/strong><\/p>\n

\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

  V\u00edce <\/p>\n","protected":false},"author":2,"featured_media":273183,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[24],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2023\/02\/14\/vedci-tit.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/273181"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=273181"}],"version-history":[{"count":3,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/273181\/revisions"}],"predecessor-version":[{"id":273249,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/273181\/revisions\/273249"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/273183"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=273181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=273181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=273181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}