{"id":273020,"date":"2023-02-12T14:10:27","date_gmt":"2023-02-12T13:10:27","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=273020"},"modified":"2023-02-12T14:11:30","modified_gmt":"2023-02-12T13:11:30","slug":"veda-neni-nuda-dat-si-prasek-rano-nebo-vecer-lithium-ovlivnuje-mozek-ruzne-behem-dne","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=273020","title":{"rendered":"V\u011aDA NEN\u00cd NUDA: D\u00e1t si pr\u00e1\u0161ek r\u00e1no, nebo ve\u010der? Lithium ovliv\u0148uje mozek \u010dlov\u011bka r\u016fzn\u011b b\u011bhem dne"},"content":{"rendered":"
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Ilustra\u010dn\u00ed foto: pixabay<\/figcaption><\/figure>\n

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Lithium se v\u00edce ne\u017e 70 let pou\u017e\u00edv\u00e1 jako \u00fa\u010dinn\u00fd l\u00e9k pro stabilizaci n\u00e1lady nap\u0159\u00edklad u pacient\u016f s bipol\u00e1rn\u00ed poruchou. Mechanismus jeho terapeutick\u00e9ho \u00fa\u010dinku v\u0161ak st\u00e1le nen\u00ed dob\u0159e zn\u00e1m. T\u00fdm Aleny Sumov\u00e9 z Fyziologick\u00e9ho \u00fastavu AV \u010cR nyn\u00ed prok\u00e1zal, \u017ee lithium ovliv\u0148uje hodiny v \u010d\u00e1sti mozku zvan\u00e9 choroid plexus, jeho\u017e \u00faloha souvis\u00ed s \u201e\u00faklidem\u201c v mozku b\u011bhem sp\u00e1nku. V\u00fdsledky, publikovan\u00e9 v presti\u017en\u00edm \u010dasopise Biomedicine a Pharmacotherapy, ukazuj\u00ed na d\u016fle\u017eitost spr\u00e1vn\u00e9ho na\u010dasov\u00e1n\u00ed l\u00e9\u010dby lithiem b\u011bhem dne.<\/h6>\n

\"\"L\u00e9\u010dba lithiem z\u016fst\u00e1v\u00e1 \u201ezlat\u00fdm standardem\u201c l\u00e9\u010dby prevence recidiv bipol\u00e1rn\u00ed poruchy, a to jak typu I (s m\u00e1ni\u00ed a velkou depres\u00ed), tak typu II (s depres\u00ed a hypom\u00e1ni\u00ed). Jak lithium konkr\u00e9tn\u011b ovliv\u0148uje \u010dinnost mozku, v\u0161ak nen\u00ed dosud zcela odhaleno.<\/p>\n

Nov\u00e9 poznatky p\u0159inesl v\u00fdzkum Odd\u011blen\u00ed biologick\u00fdch rytm\u016f ve Fyziologick\u00e9m \u00fastavu AV \u010cR pod veden\u00edm Aleny Sumov\u00e9. V\u011bdci se zab\u00fdvali studiem vlivu lithia na cirkadi\u00e1nn\u00ed (denn\u00ed) hodiny um\u00edst\u011bn\u00e9 v komplexu komorov\u00e9 bari\u00e9ry obsahuj\u00edc\u00ed choroidn\u00ed plexus. Choroidn\u00ed plexus je hust\u011b prokrven\u00e1 \u010d\u00e1st mozku, jej\u00ed\u017e hlavn\u00ed funkc\u00ed je v\u00fdroba mozkom\u00ed\u0161n\u00edho moku. \u201eZjistili jsme, \u017ee pod\u00e1n\u00ed lithia u my\u0161\u00ed zm\u011bnilo v t\u00e9to \u010d\u00e1sti mozku \u00farove\u0148 exprese tzv. hodinov\u00e9ho genu, tedy genu, kter\u00fd je z\u00e1sadn\u00ed pro chod cirkadi\u00e1nn\u00edch hodin,\u201c<\/em> vysv\u011btluje Alena Sumov\u00e1.<\/p>\n

Pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f na m\u00edru<\/h6>\n

K podrobn\u011bj\u0161\u00edmu studiu \u00fa\u010dinku lithia v\u011bdci pou\u017eili model transgenn\u00ed my\u0161i s cirkadi\u00e1nn\u00edm report\u00e9rem (mPer2LUC) a sledovali chod biologick\u00fdch hodin choroid\u00e1ln\u00edho plexu v re\u00e1ln\u00e9m \u010dase. Kdy\u017e aplikovali lithium na choroidn\u00ed plexus izolovan\u00fd z t\u011bchto my\u0161\u00ed a kultivovali jej v in vitro podm\u00ednk\u00e1ch, zjistili, \u017ee lithium po v\u011bt\u0161inu dne hodiny zpo\u017e\u010fovalo, ale v jin\u00e9 \u010d\u00e1sti dne m\u011blo na chod hodin opa\u010dn\u00fd efekt. \u00da\u010dinek na hodiny byl tedy vysoce z\u00e1visl\u00fd na na\u010dasov\u00e1n\u00ed aplikace. Podrobn\u011bji pak prozkoumali mechanismus p\u016fsoben\u00ed lithia v t\u00e9to \u010d\u00e1sti mozku i na molekul\u00e1rn\u00ed \u00farovni.<\/p>\n

V\u00fdsledky odhaluj\u00ed nov\u00fd mechanismus p\u016fsoben\u00ed lithia, kter\u00e9 se\u0159izuje hodiny choroidn\u00edho plexu. \u201eTo m\u016f\u017ee zlep\u0161it funkce mozku u psychiatrick\u00fdch pacient\u016f a b\u00fdt tak sou\u010d\u00e1st\u00ed terapeutick\u00e9ho efektu tohoto l\u00e9ku. Nov\u00e9 poznatky podep\u0159en\u00e9 daty tak argumentuj\u00ed pro to, aby na\u010dasov\u00e1n\u00ed l\u00e9\u010dby lithiem u pacient\u016f s bipol\u00e1rn\u00ed depres\u00ed bylo personalizovan\u00e9 \u010dili \u201eu\u0161it\u00e9\u201c pacient\u016fm na m\u00edru,\u201c<\/em> uv\u00e1d\u00ed Alena Sumov\u00e1.<\/p>\n

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(tz-av\u010dr)<\/strong><\/p>\n

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  Lithium <\/p>\n","protected":false},"author":2,"featured_media":273022,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[24,174],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2023\/02\/11\/stres-bolest-hlavy.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/273020"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=273020"}],"version-history":[{"count":3,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/273020\/revisions"}],"predecessor-version":[{"id":273050,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/273020\/revisions\/273050"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/273022"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=273020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=273020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=273020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}