{"id":258157,"date":"2022-07-03T14:37:56","date_gmt":"2022-07-03T13:37:56","guid":{"rendered":"https:\/\/zakrasnejsivimperk.cz\/?p=258157"},"modified":"2022-07-05T17:00:50","modified_gmt":"2022-07-05T16:00:50","slug":"veda-neni-nuda-umela-inteligence-pomuze-stanovit-diagnozu-pacientu","status":"publish","type":"post","link":"https:\/\/zakrasnejsivimperk.cz\/?p=258157","title":{"rendered":"V\u011aDA NEN\u00cd NUDA: Projekt. Um\u011bl\u00e1 inteligence pom\u016f\u017ee stanovit diagn\u00f3zu pacient\u016f"},"content":{"rendered":"
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T\u00fdm Biologick\u00e9ho centra AV \u010cR, vedouc\u00ed projektu Lucie \u0158imn\u00e1\u010dov\u00e1 a vedouc\u00ed Laborato\u0159e analytick\u00e9 biochemie a metabolomiky Petr \u0160imek (stoj\u00edc\u00ed), v pop\u0159ed\u00ed Martin Moos.<\/figcaption><\/figure>\n

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Um\u011bl\u00e1 inteligence bude pom\u00e1hat p\u0159i stanovov\u00e1n\u00ed diagn\u00f3zy pacient\u016f na z\u00e1klad\u011b jejich laboratorn\u00edch vzork\u016f. Na unik\u00e1tn\u00ed pilotn\u00ed technologii MAIA spolupracuje Biologick\u00e9 centrum Akademie v\u011bd \u010cR (BC AV), Nemocnice \u010cesk\u00e9 Bud\u011bjovice a biotechnologick\u00e1 spole\u010dnost Aiolite. Projekt spolufinancovala Technologick\u00e1 agentura \u010cR a vyvrchol\u00ed na konci \u010dervna leto\u0161n\u00edho roku. V\u00fdsledkem spolupr\u00e1ce bude v\u00fdvoj pokro\u010dil\u00e9ho softwarov\u00e9ho n\u00e1stroje, kter\u00fd l\u00e9ka\u0159\u016fm pom\u016f\u017ee v rozhodov\u00e1n\u00ed o l\u00e9\u010db\u011b pacienta.<\/h6>\n

\"\"C\u00edlem projektu MAIA (Metabolomic Artificial Intelligence Analysis) bylo propojit data z\u00edsk\u00e1van\u00e1 ze vzork\u016f mo\u010di a krve pacient\u016f a vyvinout s pomoc\u00ed metod um\u011bl\u00e9 inteligence efektivn\u00ed n\u00e1stroj pro jejich anal\u00fdzu a synt\u00e9zu. V\u00fdsledky budou slou\u017eit l\u00e9ka\u0159\u016fm ke sledov\u00e1n\u00ed v\u00fdvoje zdravotn\u00edho stavu pacienta a volb\u011b dal\u0161\u00edho l\u00e9\u010debn\u00e9ho postupu.<\/p>\n

Projekt MAIA je \u00fasp\u011b\u0161n\u00fdm pr\u030c\u00edkladem propojen\u00ed v\u00fdsledk\u016f v\u00fdzkumu s klinickou medic\u00ednou a pr\u016fmyslem. Pod\u00edl\u00ed se na n\u011bm tr\u030ci t\u00fdmy odborn\u00edk\u016f – l\u00e9ka\u0159i, v\u00fdzkumn\u00edci a informatici, kter\u00e9 jsou r\u030c\u00edzen\u00e9 mlad\u00fdmi vedouc\u00edmi pracovn\u00edky pod dohledem mentoru\u030a.<\/p>\n

L\u00e9ka\u0159i z \u010deskobud\u011bjovick\u00e9 nemocnice vybrali pro pilotn\u00ed projekt pacienty z jednotky intenzivn\u00ed p\u00e9c\u030ce Infekc\u030cn\u00edho odde\u030clen\u00ed s podezr\u030cen\u00edm na mo\u017en\u00fd rozvoj septick\u00fdch komplikac\u00ed. Ze standardn\u00edch odbe\u030cru\u030a biologick\u00e9ho materi\u00e1lu pr\u030ced\u00e1vaj\u00ed pr\u030ci -20 stupn\u00edch zpracovan\u00e9 anonymizovan\u00e9 vzorky do biochemick\u00e9 laborator\u030ce BC AV \u010cR. Z\u00e1rove\u0148 k vzorku\u030am odes\u00edlaj\u00ed do \u00falo\u017ei\u0161te\u030c MAIA anonymizovan\u00e9 klinick\u00e9 \u00fadaje o stavu pacienta, jeho l\u00e9c\u030cbe\u030c a tak\u00e9 laboratorn\u00ed v\u00fdsledky v\u00e1zan\u00e9 na c\u030cas a pru\u030abe\u030ch onemocne\u030cn\u00ed. Biochemici z BC AV \u010cR prov\u00e1d\u011bj\u00ed ve vzorc\u00edch tzv. metabolomickou anal\u00fdzu \u201eVyu\u017e\u00edv\u00e1me nejnov\u011bj\u0161\u00ed poznatky a metody z v\u00fdzkumu metabolismu. V nepatrn\u00e9m objemu vzorku lidsk\u00e9ho krevn\u00edho s\u00e9ra nebo mo\u010di dok\u00e1\u017eeme sou\u010dasn\u011b zm\u011b\u0159it zhruba o \u0159\u00e1d v\u00edce l\u00e1tek, ne\u017e se dnes obvykle z\u00edsk\u00e1v\u00e1 p\u0159i standardn\u00edch klinick\u00fdch rozborech,\u201c<\/em> r\u030c\u00edk\u00e1 Petr \u0160imek, vedouc\u00ed Laborato\u0159e analytick\u00e9 biochemie a metabolomiky Biologick\u00e9ho centra.<\/p>\n

\"\"<\/a>
Jakub Sch\u016frek<\/figcaption><\/figure>\n

Z\u00edskan\u00e9 obrovsk\u00e9 soubory dat pak analyzuje, t\u0159\u00edd\u00ed a vyhodnocuje softwarov\u00fd n\u00e1stroj MAIA s algoritmy um\u011bl\u00e9 inteligence firmy Aiolite. \u201eTato tzv. big data obsahuj\u00ed informace o \u0161irok\u00e9 \u0161k\u00e1le potenci\u00e1ln\u00edch biomarker\u016f a pou\u017eit\u00e9 medikaci, kter\u00e9 vyhodnot\u00ed n\u00e1\u0161 server vybaven\u00fd um\u011blou inteligenc\u00ed. O\u0161et\u0159uj\u00edc\u00ed l\u00e9ka\u0159 dostane k posouzen\u00ed aktu\u00e1ln\u00edho zdravotn\u00edho stavu pacienta ucelen\u00e9 podklady, kter\u00e9 mu pomohou na kvalitativn\u011b vy\u0161\u0161\u00ed \u00farovni rozhodovat o dal\u0161\u00edm, optim\u00e1ln\u00edm postupu l\u00e9\u010dby. Tento n\u00e1stroj tak m\u016f\u017ee pacientovi zlep\u0161it kvalitu \u017eivota, pota\u017emo zachr\u00e1nit \u017eivot,\u201c<\/em> vysv\u011btluje Jakub Sch\u016frek, CEO firmy Aiolite.<\/p>\n

Funkc\u030cnost platformy MAIA je pru\u030abe\u030c\u017ene\u030c kontrolov\u00e1na tak\u00e9 paraleln\u00edm ruc\u030cn\u00edm zpracov\u00e1n\u00edm pomoc\u00ed konvenc\u030cn\u00edch metod. Z\u00e1ve\u030crec\u030cn\u00e9 hodnocen\u00ed v\u00fdsledku\u030a anal\u00fdz prov\u00e1d\u011bl t\u00fdm l\u00e9kar\u030cu\u030a infekc\u030cn\u00edho odde\u030clen\u00ed, klinick\u00e9 biochemie a dal\u0161\u00edch odborn\u00edku\u030a z laboratorn\u00ed medic\u00edny. C\u00edlem projektu bylo vytvo\u0159it pilotn\u00ed n\u00e1stroje pro komplexn\u00ed propojen\u00ed, zpracov\u00e1n\u00ed a vyt\u011b\u017eov\u00e1n\u00ed v\u0161ech dostupn\u00fdch klinick\u00fdch dat se z\u00e1m\u011brem vyhled\u00e1vat nov\u00e9, dosud nepoznan\u00e9 souvislosti a poznatky a vyu\u017e\u00edt je v klinick\u00e9 diagnostice.<\/p>\n

V\u00fdzkumn\u00edci nov\u00e9 p\u0159\u00edstupy nejprve testovali na vybran\u00fdch modelech bun\u011b\u010dn\u00fdch kultur, jejich\u017e fyziologick\u00fd stav lze l\u00e9pe kontrolovat. Pot\u00e9 pokra\u010dovali na prim\u00e1rn\u00edch lymfocytech, a nakonec na vzorc\u00edch pacient\u016f v septick\u00e9m stavu.<\/p>\n

\u201eProjekt n\u00e1s zaujal vyu\u017eit\u00edm \u0161irok\u00e9ho spektra stanoviteln\u00fdch parametru\u030a pr\u030ceme\u030cny l\u00e1tkov\u00e9 v lidsk\u00e9m organismu, kter\u00e9 skr\u00fdv\u00e1 potenci\u00e1l k hodnocen\u00ed energetick\u00e9ho stavu organismu, schopnosti produkovat potr\u030cebn\u00e9 l\u00e1tky a hodnocen\u00ed efektu l\u00e9c\u030cebn\u00fdch opatr\u030cen\u00ed. Vzhledem k mno\u017estv\u00ed me\u030cr\u030citeln\u00fdch parametru\u030a, jejich dynamiky, vlivu biorytmu\u030a, re\u017eimu l\u00e9c\u030cby a dal\u0161\u00edch faktoru\u030a je velmi te\u030c\u017ek\u00e9 bez vyu\u017eit\u00ed prvku\u030a ume\u030cl\u00e9 inteligence hledat vzory vhodn\u00e9 k posouzen\u00ed limitn\u00edch situac\u00ed vhodn\u00fdch pro volbu dal\u0161\u00edho postupu c\u030ci z\u00e1sadn\u00ed zme\u030cny strategie,\u201c<\/em> uvedl r\u030ceditel \u00faseku centr\u00e1ln\u00edch laborator\u030c\u00ed Nemocnice C\u030cesk\u00e9 Bude\u030cjovice Miroslav Verner.<\/p>\n

D\u00edky \u0161pic\u030ckov\u00e9 analytick\u00e9 technice a mo\u017enostem ume\u030cl\u00e9 inteligence by me\u030cl podle Vernera vzniknout ove\u030cr\u030cen\u00fd n\u00e1stroj, kter\u00fd zdravotn\u00edku\u030am pomu\u030a\u017ee vc\u030cas odhalit zlomov\u00e9 body pro rozhodov\u00e1n\u00ed, aby sn\u00ed\u017eili poc\u030cet \u00famrt\u00ed na sepsi a t\u00e9\u017e zefektivnili a zkr\u00e1tili dobu l\u00e9c\u030cby a rekonvalescence.<\/p>\n

V\u00fdstupem pilotn\u00edho projektu MAIA bude optimalizovan\u00e9 nastaven\u00ed proces\u016f a p\u0159esn\u00fdch postup\u016f pro vyhodnocov\u00e1n\u00ed dat pomoc\u00ed um\u011bl\u00e9 inteligence, kter\u00e9 umo\u017en\u00ed posunout projekt do dal\u0161\u00ed f\u00e1ze ov\u011b\u0159en\u00ed funk\u010dnosti syst\u00e9mu na v\u011bt\u0161\u00edm souboru pacient\u016f.<\/p>\n

Spolupr\u00e1ce bude pokra\u010dovat. \u201eSpolupr\u00e1ce s kolegy je naprosto perfektn\u00ed. Vytvo\u0159ili jsme funk\u010dn\u00ed t\u00fdm odborn\u00edk\u016f a specialist\u016f, kte\u0159\u00ed maj\u00ed i nad\u00e1le ambici pracovat na projektech, kter\u00e9 umo\u017en\u00ed propojen\u00ed poznatk\u016f v\u00fdzkumu s komer\u010dn\u00ed prax\u00ed. Finalizujeme projekt MAIA II, v r\u00e1mci kter\u00e9ho poznatky a z\u00e1v\u011bry z jedni\u010dky posuneme do dal\u0161\u00ed f\u00e1ze ov\u011b\u0159ov\u00e1n\u00ed a mo\u017enost\u00ed vyu\u017eit\u00ed,\u201d<\/em> dod\u00e1v\u00e1 Jakub Sch\u016frek.<\/p>\n

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  • Co je to sepse:\u00a0<\/strong>Sepse je v\u00edce\u00farov\u0148ov\u00e1 syst\u00e9mov\u00e1 odpov\u011b\u010f lidsk\u00e9ho organismu na infekci. Rozvoj sepse z\u00e1vis\u00ed na stavu organismu, p\u0159\u00ed\u010din\u011b, kter\u00e1 ji vyvolala, a vhodn\u00e9 l\u00e9\u010db\u011b. Nejde o uniformn\u00ed onemocn\u011bn\u00ed, ale o dynamick\u00fd stav. V sou\u010dasnosti je sepse v 35 % p\u0159\u00edpad\u016f nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed na jednotk\u00e1ch intenzivn\u00ed p\u00e9\u010de. Ro\u010dn\u011b nar\u016fst\u00e1 mno\u017estv\u00ed septick\u00fdch komplikac\u00ed o 1,5 %.<\/li>\n<\/ul>\n
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    Text a foto: (tz-av\u010dr)<\/strong><\/p>\n

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    \"\"
    Na sn\u00edmku (zleva) MUDr. Jan Vojt\u00ed\u0161ek a MUDr. Miroslav Verner z Nemocnice \u010cesk\u00e9 Bud\u011bjovice<\/figcaption><\/figure>\n
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      Um\u011bl\u00e1 <\/p>\n","protected":false},"author":2,"featured_media":258163,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[24,174],"tags":[],"jetpack_featured_media_url":"https:\/\/zakrasnejsivimperk.cz\/wp-content\/uploads\/2022\/07\/03\/um\u011bl\u00e1-inteligence-1-tit.jpg","_links":{"self":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/258157"}],"collection":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=258157"}],"version-history":[{"count":2,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/258157\/revisions"}],"predecessor-version":[{"id":258164,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/posts\/258157\/revisions\/258164"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=\/wp\/v2\/media\/258163"}],"wp:attachment":[{"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=258157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=258157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zakrasnejsivimperk.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=258157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}